Journal
HELIYON
Volume 8, Issue 10, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.heliyon.2022.e10967
Keywords
Monosodium glutamate; Progesterone; Oestrogen; Toxicity; Molecular docking
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Funding
- Universiti Malaya [ST070-2021]
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The study investigated the toxic effects of MSG on the uterus in rats, revealing alterations in hormone levels and changes in uterine structure. Therefore, caution should be exercised when using MSG, especially for females at risk of hormonal abnormalities.
Monosodium glutamate (MSG) is commonly used worldwide as a food flavour enhancer by the food industry. The current study investigated the in vivo toxic effects of MSG on the uterus in adult female Sprague Dawley rats and in vitro using MCF-7 and MDA-MB-231 cells, computational toxicity and molecular docking. The average levels of progesterone and oestrogen in the MSG-treated animals significantly altered. Besides, the average uterine lumen area (mu m2) was smaller than the control group. MSG showed high-affinity binding to acetylcholine receptors and disrupted the normal nerve signal with a predicted LD50 of 4500 mg/kg. MSG also demonstrated good binding affinity to human oestrogen receptors beta and some other proteins that have an oxidative stress role in the female reproductive organs. Therefore, a precaution should be taken when utilising this compound, especially for females under the risk factor of hormonal abnormality.
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