Journal
HELIYON
Volume 8, Issue 8, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.heliyon.2022.e10450
Keywords
Anti-cancer immunity; Cancer; CD8(+) T cells; CD4(+) T cells; Regulatory T cells; Tumor-infiltrating lymphocytes
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Funding
- Science and Engineering Research Board, Department of Science and Technology (SERB-DST) , New Delhi, India [CRG/2021/002419]
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Regulatory T cells (Tregs) are important in immune tolerance and suppressing inflammation, but their activity hinders anti-cancer immune responses. Suppressing Treg activity is a novel and effective approach for successful cancer immunotherapy, and there is growing interest in utilizing Tregs to enhance anti-cancer immunity. This review summarizes the crucial mechanisms of Tregs' suppression of anti-cancer immunity and discusses strategies to suppress or alter Tregs to improve immune response against tumors.
Regulatory T cells (Tregs) play an essential role in maintaining immune tolerance and suppressing inflammation. However, Tregs present major hurdle in eliciting potent anti-cancer immune responses. Therefore, curbing the activity of Tregs represents a novel and efficient way towards successful immunotherapy of cancer. Moreover, there is an emerging interest in harnessing Treg-based strategies for augmenting anti-cancer immunity in different types of the disease. This review summarises the crucial mechanisms of Tregs' mediated suppression of anti-cancer immunity and strategies to suppress or to alter such Tregs to improve the immune response against tu-mors. Highlighting important clinical studies, the review also describes current Treg-based therapeutic in-terventions in cancer, and discusses Treg-suppression by molecular targeting, which may emerge as an effective cancer immunotherapy and as an alternative to detrimental chemotherapeutic agents.
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