Journal
AIDS AND BEHAVIOR
Volume 27, Issue 3, Pages 1030-1043Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10461-022-03841-z
Keywords
dapivirine vaginal ring; HIV Pre-Exposure Prophylaxis; microbicide; acceptance; African women; choice
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This study investigated the use of the dapivirine vaginal ring and found that changing the dispensation schedule from monthly to quarterly did not have a negative impact on acceptance. Having a primary partner who knew about the ring, using long-acting contraception, and having a strong intention to use the ring in the future were associated with higher acceptance rates.
MTN-025/HOPE was an open-label trial of the dapivirine vaginal ring conducted in four African countries between 2016 and 2018. Women were first offered one ring monthly (at baseline, months 1 and 2), thereafter, transitioned to a more applicable real-world dispensation schedule, - 3 rings quarterly (at months 3, 6 and 9). Logistic regression analysis was used to assess correlates of ring acceptance at baseline and through follow-up. A total of 1456 women (median age 31 years) enrolled, 1342 (92.2%) accepted the ring at baseline and 1163 (79.9%) accepted the ring(s) at all visits. Changing ring dispensation from a monthly to a quarterly schedule had no negative effect on acceptance. Having a primary partner and him knowing about the ring being offered in HOPE, use of long-acting contraception (implants, injections, IUDs) or sterilization were associated with ring acceptance, along with prior strong intention to use the ring in the future. Efforts should consider these factors when rolling out the ring for HIV prevention.
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