4.7 Article

Biocompatible Magnetic Conjugated Polymer Nanoparticles for Optical and Lifetime Imaging Applications in the Fir s t Biological Window

Journal

ACS APPLIED POLYMER MATERIALS
Volume -, Issue -, Pages -

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acsapm.2c01153

Keywords

conjugated polymers; nanoparticles; biological imaging; cytotoxicity studies; fluorescence lifetime studies; zebrafish

Funding

  1. ERC Starting (Consolidator) [306659]
  2. Wellcome Investigator Award [110060/Z/15/Z]
  3. European Research Council (ERC) [306659] Funding Source: European Research Council (ERC)
  4. Wellcome Trust [110060/Z/15/Z] Funding Source: Wellcome Trust

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This study reports the encapsulation of a bright-red-emitting conjugated polymer and superparamagnetic iron oxide nanoparticles in polymer micelles. The resulting particles exhibited good emission properties and cellular uptake, making them potentially valuable for in vivo labeling applications.
Conjugated polymers are organic semiconductors that can be used for fluorescence microscopy of living specimens. Here, we report the encapsulation of the bright-red-emitting conjugated polymer, poly[{9,9-dihexyl-2,7-bis(1-cyanovinylene)- fluorenylene}-alt-co-{2,5-bis(N,N '-diphenylamino)-1,4-phenyl-ene}] (CN-FO-DPD), and superparamagnetic iron oxide nano-particles (SPIONs) within poly(styrene-co-maleic anhydride) (PSMA) micelles. The resulting particles exhibited an emission peak at 657 nm, a fluorescence quantum yield of 21%, an average diameter of 65 nm, and a zeta potential of -30 mV. They are taken up by cells, and we describe their use in fluorescence microscopy of living Hela cells and zebrafish embryos and their associated cytotoxicity in HEK, HeLa, and HCE cells.

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