Journal
ACS APPLIED POLYMER MATERIALS
Volume 4, Issue 10, Pages 6784-6796Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsapm.2c01291
Keywords
star polymers; cancer; chemotherapy; siRNA; theranostics
Funding
- National Health and Medical Research Council [APP1196850]
- UQ Foundation Research Excellence Award (UQFREA) , UQ Amplify Women's Academic Research Equity (UQAWARE)
- Advance Queensland Women's Research Assistance Program
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Star polymers have unique structures and properties for drug delivery and imaging agent design. Previous studies have shown their potential translational applications. This review summarizes research published in the past 5 years and provides insights into the future clinical translation of star polymer nanoparticles through advanced models.
Star polymers are structures composed of multiple functional linear arms covalently connected through a central core. The unique conformation of star polymers, with their tunable side arms and architectural plasticity, makes them well equipped to deliver pharmaceutical drugs and biologicals (peptides, nucleic acids), and design imaging agents. A great deal has been reported on the design and synthesis of star polymers, with several studies demonstrating the possibility for future translation. In this work, we have for the first time performed a review on research published over the last 5-years, focused on the translation of star polymer nanoparticles toward therapeutic application. We discuss all the important potential translational breakthroughs in the field as well as offering a perspective on how the addition of cutting-edge in vitro and in vivo models could provide us with the tools for the successful future clinical translation of star polymer nanoparticles.
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