Journal
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
Volume 14, Issue 8, Pages 867-873Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4240/wjgs.v14.i8.867
Keywords
Helicobacter pylori; Gastric cancer; Eradication rate; Metachronous gastric cancer
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Eradication of H. pylori significantly reduces the risk of metachronous gastric cancer after endoscopic resection in the East Asian population. However, factors such as increasing age, severe atrophy in the corpus and antrum, and intestinal metaplasia may increase the risk of metachronous gastric cancer in H. pylori eradicated patients.
We conducted a comprehensive literature review and meta-analysis study on the efficacy of Helicobacter pylori (H. pylori) eradication in preventing metachronous gastric cancer after endoscopic resection among an East Asian population. Our results showed that the eradication of this pathogen significantly reduced the risk of susceptibility to metachronous gastric cancer in these patients. However, based on the available evidence, several factors such as increasing age, severe atrophy in the corpus and antrum, and intestinal metaplasia all may increase the risk of metachronous gastric cancer in H. pylori eradicated patients.
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