4.7 Review

State-of-the-Art Advances of Nanomedicine for Diagnosis and Treatment of Bladder Cancer

Journal

BIOSENSORS-BASEL
Volume 12, Issue 10, Pages -

Publisher

MDPI
DOI: 10.3390/bios12100796

Keywords

bladder cancer; nanomedicine; diagnostic methods; drugs delivery

Funding

  1. National Natural Science Foundation of China [82102171]
  2. Guangdong Basic and Applied Basic Research Foundation [2021A1515110402, 2021A1515220156]
  3. China Postdoctoral Science Foundation [2020M682948]
  4. Shenzhen Excellent Science and Technology Innovation Talents Training Project [RCBS20200714114857172]
  5. Shenzhen Scientific and technological Research Program [JSGG20201103153801005]

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This article presents an overview of the new advancements in nano-platforms for the diagnosis and treatment of bladder cancer, including the potential of nanomedicine in reducing side effects, enhancing tumor inhibition effects, and overcoming drug resistance.
Bladder cancer is a common malignant tumor of the urinary system. Cystoscopy, urine cytology, and CT are the routine diagnostic methods. However, there are some problems such as low sensitivity and difficulty in staging, which must be urgently supplemented by novel diagnostic methods. Surgery, intravesical instillation, systemic chemotherapy, and radiotherapy are the main clinical treatments for bladder cancer. It is difficult for conventional treatment to deal with tumor recurrence, progression and drug resistance. In addition, the treatment agents usually have the defects of poor specific distribution ability to target tumor tissues and side effects. The rapid development of nanomedicine has brought hope for the treatment of bladder cancer in reducing side effects, enhancing tumor inhibition effects, and anti-drug resistance. Overall, we review the new progression of nano-platforms in the diagnosis and treatment of bladder cancer.

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