Journal
JOURNAL OF MICROENCAPSULATION
Volume 33, Issue 4, Pages 323-330Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/02652048.2016.1185475
Keywords
Piroxicam; nanospheres; electrospraying technique; solubility; oral bioavailability
Funding
- National Research Foundation of Korea (NRF) grant - Korea government (MEST) [2015R1A2A2A05027872]
- National Research Foundation of Korea [2015R1A2A2A05027872] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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To determine if a novel electrospraying technique could be applied to an oral drug delivery system for improving the solubility and oral bioavailability of poorly water-soluble piroxicam; the nanospheres were generated with drug and polyvinylpyrrolidone (PVP) using electrospraying technique; and their physicochemical properties, solubility, release and pharmacokinetics were evaluated in comparison with piroxicam powder. All nanospheres had significantly increased drug solubility and dissolution rates in comparison with the drug powder. In particular, the nanosphere composed of piroxicam and PVP at a weight ratio of 2:8 gave about 600-fold higher solubility, 15-fold higher release rate and 3-fold higher AUC in comparison to piroxicam powder, leading to significantly enhanced oral bioavailability in rats, due to the mingled effect of nanonisation along with transformation to the amorphous state. Thus, this electrospraying technique can be utilised to produce a novel oral nanosphere delivery system with enhanced solubility and oral bioavailability for poorly water-soluble piroxicam.
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