Journal
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
Volume 11, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s40164-022-00343-5
Keywords
RNA binding protein; MLL; Leukemia
Categories
Funding
- Tumor Cell Biology Training Grant [NIH T32 CA009056]
- NIH/NCI [R21 CA197441, R01 CA166450, R01CA264986]
- American Society of Hematology Bridge Grant
- UCLA Jonsson Comprehensive Cancer Center Seed Grant
- STOPCancer/Barbara and Gary Luboff Mitzvah Fund Seed Grant
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RNA binding proteins (RBPs) have emerged as important regulators of post-transcriptional gene expression, influencing mRNA fate through multiple mechanisms and critically impacting oncogenic transcript expression. This article focuses on the major features and mechanisms of RBPs, and discusses the current progress in investigating the function of important RBPs in MLL-rearranged leukemia.
RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene expression regulators in both normal development and disease. RBPs influence the fate of mRNAs through multiple mechanisms of action such as RNA modifications, alternative splicing, and miR-mediated regulation. This complex and, often, combinatorial regulation by RBPs critically impacts the expression of oncogenic transcripts and, thus, the activation of pathways that drive oncogenesis. Here, we focus on the major features of RBPs, their mechanisms of action, and discuss the current progress in investigating the function of important RBPs in MLL-rearranged leukemia.
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