4.6 Review

Reduction or de-escalation of dual antiplatelet therapy intensity or duration in patients with acute coronary syndromes undergoing percutaneous coronary intervention: A mini-review

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Short Duration of DAPT Versus De-Escalation After Percutaneous Coronary Intervention for Acute Coronary Syndromes

Claudio Laudani et al.

Summary: This study compares the effectiveness of short dual antiplatelet therapy (DAPT) and de-escalation in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). The results suggest that de-escalation reduces the risk of adverse cardiovascular events, while short DAPT decreases the occurrence of major bleeding.

JACC-CARDIOVASCULAR INTERVENTIONS (2022)

Article Cardiac & Cardiovascular Systems

Prasugrel-based De-Escalation of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients With STEMI

You-Jeong Ki et al.

Summary: Dose reduction of prasugrel can decrease adverse clinical events and bleeding in NSTE-ACS patients, but it does not show significant improvement in STEMI patients.

KOREAN CIRCULATION JOURNAL (2022)

Article Cardiac & Cardiovascular Systems

Comparison of Clopidogrel Monotherapy After 1 to 2 Months of Dual Antiplatelet Therapy With 12 Months of Dual Antiplatelet Therapy in Patients With Acute Coronary Syndrome The STOPDAPT-2 ACS Randomized Clinical Trial

Hirotoshi Watanabe et al.

Summary: In patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI), clopidogrel monotherapy after 1 to 2 months of dual antiplatelet therapy (DAPT) did not demonstrate noninferiority to 12 months of DAPT for the composite end point of cardiovascular and bleeding events.

JAMA CARDIOLOGY (2022)

Review Cardiac & Cardiovascular Systems

Comparison of Unguided De-Escalation Versus Guided Selection of Dual Antiplatelet Therapy After Acute Coronary Syndrome: A Systematic Review and Network Meta-Analysis

Toshiki Kuno et al.

Summary: Compared with guided selection of DAPT, unguided de-escalation of DAPT decreases bleeding risk in patients after acute coronary syndrome.

CIRCULATION-CARDIOVASCULAR INTERVENTIONS (2022)

Article Cardiac & Cardiovascular Systems

2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Jean-Philippe Collet et al.

EUROPEAN HEART JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

Viscoelastic properties of clot formation and their clinical impact in East Asian versus Caucasian patients with stable coronary artery disease: a COMPARE-RACE analysis

Young-Hoon Jeong et al.

Summary: This study showed differences in viscoelastic properties of clot formation between East Asian and Caucasian patients with stable CAD. High platelet-fibrin clot strength (PFCS) was significantly associated with major adverse cardiovascular events (MACE), and East Asian patients had a lower prevalence of high PFCS compared to Caucasians. Further research is needed to fully understand the mechanisms and clinical significance of these findings.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

Article Hematology

Pharmacodynamic Profile and Prevalence of Bleeding Episode in East Asian Patients with Acute Coronary Syndromes Treated with Prasugrel Standard-Dose versus De-escalation Strategy: A Randomized A-MATCH Trial

Young-Hoon Jeong et al.

Summary: Compared with standard-dose prasugrel, the de-escalation strategy in East Asian patients with ACS showed a higher chance within the therapeutic window and a lower tendency toward bleeding episodes.

THROMBOSIS AND HAEMOSTASIS (2021)

Article Medicine, General & Internal

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk

Marco Valgimigli et al.

Summary: The study showed that one month of dual antiplatelet therapy was noninferior to continuing therapy for at least 2 additional months in terms of net adverse clinical events and major adverse cardiac or cerebral events in patients with high risk of bleeding after drug-eluting stent implantation; abbreviated therapy also resulted in a lower incidence of major or clinically relevant nonmajor bleeding.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

Efficacy and Safety of Ticagrelor Monotherapy by Clinical Presentation: Pre-Specified Analysis of the GLOBAL LEADERS Trial

Pascal Vranckx et al.

Summary: This study analyzed the outcomes of dual antiplatelet therapy after coronary drug-eluting stent placement in patients with stable coronary artery disease (SCAD) and acute coronary syndromes (ACS). It was found that the experimental strategy could reduce bleeding risk in ACS patients, but the effect was not significant in SCAD patients.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Review Hematology

The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease

Hyun Kuk Kim et al.

Summary: East Asian patients exhibit unique risk-benefit trade-offs in antithrombotic therapies compared to Caucasian patients, necessitating further research to guide future treatment strategies.

THROMBOSIS AND HAEMOSTASIS (2021)

Article Medicine, General & Internal

Ticagrelor with or without Aspirin in High-Risk Patients after PCI

R. Mehran et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

A Genotype-Guided Strategy for Oral P2Y12 Inhibitors in Primary PCI

Daniel M. F. Claassens et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes

S. Schuepke et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Cardiac & Cardiovascular Systems

2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS

Marco Valgimigli et al.

EUROPEAN HEART JOURNAL (2018)

Article Cardiac & Cardiovascular Systems

1-Year Outcomes of Patients Undergoing Primary Angioplasty for Myocardial Infarction Treated With Prasugrel Versus Ticagrelor

Zuzana Motovska et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

Article Health Care Sciences & Services

Efficacy and safety outcomes of ticagrelor compared with clopidogrel in elderly Chinese patients with acute coronary syndrome

Huidong Wang et al.

THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2016)

Review Cardiac & Cardiovascular Systems

Duration of Dual Antiplatelet Therapy After Coronary Stenting A Review of the Evidence

Gilles Montalescot et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

Article Medicine, General & Internal

Three vs Twelve Months of Dual Antiplatelet Therapy After Zotarolimus-Eluting Stents The OPTIMIZE Randomized Trial

Fausto Feres et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

Article Medicine, General & Internal

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

Lars Wallentin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Cardiac & Cardiovascular Systems

Early and late benefits of prasugrel in patients with acute coronary syndromes undergoing percutaneous coronary intervention

Elliott M. Antman et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2008)