4.6 Article

Higher neutrophil to lymphocyte ratio is associated with renal dysfunction and cardiac adverse remodeling in elderly with metabolic syndrome

Related references

Note: Only part of the references are listed.
Review Endocrinology & Metabolism

Is the Neutrophil-to-Lymphocyte Ratio an Exceptional Indicator for Metabolic Syndrome Disease and Outcomes?

Parisa Hashemi Moghanjoughi et al.

Summary: This study demonstrates a relationship between neutrophil-to-lymphocyte ratio (NLR) and metabolic syndrome. NLR, as an inflammatory marker, is associated with obesity, diabetes, hypertension, and hyperlipidemia.

ENDOCRINE PRACTICE (2022)

Review Cardiac & Cardiovascular Systems

The prognostic value of neutrophil-to-lymphocyte ratio across all stages of coronary artery disease

Raksheeth Agarwal et al.

Summary: The development of coronary heart disease involves the inflammatory process, and the neutrophil-to-lymphocyte ratio (NLR) can be used as a predictive biomarker in assessing the prognosis and risk in patients.

CORONARY ARTERY DISEASE (2022)

Review Endocrinology & Metabolism

Insulin Resistance: From Mechanisms to Therapeutic Strategies

Shin-Hae Lee et al.

Summary: Insulin resistance, characterized by reduced responsiveness of insulin-targeting tissues to physiological levels of insulin, is a key pathogenic component of many metabolic diseases. This review summarizes the functions of insulin in glucose metabolism and discusses the mechanisms proposed for insulin resistance, such as ectopic lipid accumulation, endoplasmic reticulum stress, and inflammation. Potential therapeutic strategies for addressing insulin resistance are also suggested.

DIABETES & METABOLISM JOURNAL (2022)

Article Cardiac & Cardiovascular Systems

The neutrophil-lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials

Nicholas H. Adamstein et al.

Summary: The study demonstrates that the neutrophil-lymphocyte ratio (NLR) can predict cardiovascular events and mortality risk, and can be reduced by anti-inflammatory therapy with canakinumab.

EUROPEAN HEART JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

Association of Carotid Intima Media Thickness With Metabolic Syndrome Among Low-Income Middle-Aged and Elderly Chinese: A Population-Based Cross-Sectional Study

Qiaoxia Yang et al.

Summary: The study revealed a correlation between metabolic syndrome (MetS) and carotid intima media thickness (CIMT) in a low-income Chinese population aged >= 45 years. The risk of carotid atherosclerosis increased with the presence of multiple MetS components in middle-aged and elderly individuals. Detailed management strategies are essential for early prevention and intervention of atherosclerosis in this population.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Geriatrics & Gerontology

Glomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women

Xing Song et al.

Summary: Moderate to severe glomerular filtration dysfunction in menopausal diabetic women is associated with enlarged left-side atrioventricular chambers, increased ventricular wall thickness, decreased cardiac function, and dilated right ventricle.

CLINICAL INTERVENTIONS IN AGING (2021)

Review Biochemistry & Molecular Biology

Neutrophil-to-Lymphocyte Ratio as a Cardiovascular Risk Marker May Be Less Efficient in Women Than in Men

Ljiljana Trtica Majnaric et al.

Summary: Cardiovascular disease is the leading cause of death in women, where chronic inflammation plays a crucial role in its development along with insulin resistance and diabetes type 2. Research on sex-specific differences in the lifetime course of NLR is lacking, despite the impact of factors such as aging, menopause, hormonal changes, immune reactions, and inflammation mechanisms on CVD prevalence in both sexes.

BIOMOLECULES (2021)

Article Public, Environmental & Occupational Health

Temporal trends in the prevalence of metabolic syndrome among middle-aged and elderly adults from 2011 to 2015 in China: the China health and retirement longitudinal study (CHARLS)

Bo Liu et al.

Summary: The prevalence of Metabolic Syndrome in China ranged from 20.41% to 39.68% in 2015, with higher rates among women, elderly adults, urban populations, and those in the northern regions. The trends in prevalence decreased significantly between 2011 and 2015 by some criteria, while increasing significantly by others.

BMC PUBLIC HEALTH (2021)

Article Cardiac & Cardiovascular Systems

Impact of high neutrophil-to-lymphocyte ratio on the cardiovascular benefit of PCSK9 inhibitors in familial hypercholesterolemia subjects with atherosclerotic cardiovascular disease: Real-world data from two lipid units

Roberto Scicali et al.

Summary: NLR is a novel inflammatory biomarker strongly associated with ASCVD. This study found that FH subjects with low-NLR experienced a significant reduction of PWV after PCSK9-i therapy, suggesting a role of NLR in predicting PCSK9-i effects in this population.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

Article Multidisciplinary Sciences

Low body mass is associated with reduced left ventricular mass in Chinese elderly with severe COPD

Jing Zhang et al.

Summary: This study demonstrates that a lower BMI in COPD patients is associated with dilated right ventricle and impaired pulmonary function, as well as reduced left ventricular mass in Asian COPD elderly with severe lung dysfunction.

SCIENTIFIC REPORTS (2021)

Article Endocrinology & Metabolism

Neutrophil-to-lymphocyte ratio is a predictor of renal dysfunction in Japanese patients with type 2 diabetes

Taichi Akase et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

Article Peripheral Vascular Disease

Neutrophil to lymphocyte ratio as predictor for incident hypertension: a 9-year cohort study in Taiwan

Yi-Han Jhuang et al.

HYPERTENSION RESEARCH (2019)

Review Medical Laboratory Technology

Metabolic syndrome is an inflammatory disorder: A conspiracy between adipose tissue and phagocytes

Priya Reddy et al.

CLINICA CHIMICA ACTA (2019)

Article Medicine, General & Internal

Neutrophil-to-lymphocyte ratio as a predictive marker of metabolic syndrome

Chuan-Chuan Liu et al.

MEDICINE (2019)

Article Endocrinology & Metabolism

Cardiac structure and function with and without metabolic syndrome: the Echocardiographic Study of Latinos (Echo-SOL)

Melissa Burroughs Pena et al.

BMJ OPEN DIABETES RESEARCH & CARE (2018)

Article Geriatrics & Gerontology

Body mass index is associated with type 2 diabetes mellitus in Chinese elderly

Qianping Zhao et al.

CLINICAL INTERVENTIONS IN AGING (2017)

Review Cardiac & Cardiovascular Systems

Inflammation and metabolic cardiomyopathy

Kazuhiko Nishida et al.

CARDIOVASCULAR RESEARCH (2017)

Article Biochemistry & Molecular Biology

Lipotoxicity in obesity and diabetes-related cardiac dysfunction

Igor Zlobine et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2016)

Review Medicine, General & Internal

Renin-angiotensin-aldosterone system in insulin resistance and metabolic syndrome

Undurti N. Das

JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE (2016)

Article Peripheral Vascular Disease

Blood Neutrophil to Lymphocyte Ratio as a Predictor of Hypertension

Xing Liu et al.

AMERICAN JOURNAL OF HYPERTENSION (2015)

Article Cardiac & Cardiovascular Systems

Preclinical Left Ventricular Diastolic Dysfunction in Metabolic Syndrome

Nir Ayalon et al.

AMERICAN JOURNAL OF CARDIOLOGY (2014)

Article Hematology

Correlation of Neutrophil to Lymphocyte Ratio With the Presence and Severity of Metabolic Syndrome

Eyup Buyukkaya et al.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2014)

Article Peripheral Vascular Disease

Usefulness of the Neutrophil-to-Lymphocyte Ratio in Predicting the Severity of Coronary Artery Disease: A Gensini Score Assessment

Juan Chen et al.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2014)

Review Cardiac & Cardiovascular Systems

Cardiomyocyte changes in the metabolic syndrome and implications for endogeneous protective strategies

Wouter Oosterlinck et al.

EXPERT REVIEW OF CARDIOVASCULAR THERAPY (2014)

Article Peripheral Vascular Disease

Role of Renin-Angiotensin-Aldosterone System in Metabolic Syndrome and Obesity-related Hypertension

Kei Kamide

CURRENT HYPERTENSION REVIEWS (2013)

Article Cardiac & Cardiovascular Systems

Aldosterone-induced brain MAPK signaling and sympathetic excitation are angiotensin II type-1 receptor dependent

Zhi-Hua Zhang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2012)

Article Medicine, General & Internal

Estimating Glomerular Filtration Rate from Serum Creatinine and Cystatin C

Lesley A. Inker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Nutrition & Dietetics

Renal Dysfunction, Metabolic Syndrome and Cardiovascular Disease Mortality

David Martins et al.

JOURNAL OF NUTRITION AND METABOLISM (2010)

Article Cardiac & Cardiovascular Systems

Metabolic Syndrome, Inflammation, and Incident Heart Failure in the Elderly The Cardiovascular Health Study

Takeki Suzuki et al.

CIRCULATION-HEART FAILURE (2008)

Article Medicine, General & Internal

The metabolic syndrome increases cardiovascular mortality in Taiwanese elderly

C. J. Wen et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2008)

Article Physiology

Lipotoxic and inflammatory phenotypes in rats with uncontrolled metabolic syndrome and nephropathy

Jesus Dominguez et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)