Journal
FRONTIERS IN CARDIOVASCULAR MEDICINE
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2022.921204
Keywords
neutrophil; lymphocyte ratio; inflammation; renal dysfunction; cardiac remodeling; metabolic syndrome; elderly; age; gender
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Funding
- Natural Science Research Fund of the Medical Science and Technology Research Fund of Health Bureau of Chongqing City, China [04-2-154, 2009-2-290]
- Chongqing Science and Technology Commission in Chongqing City, China (CSTC) [2007BB5276]
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The study found that in elderly individuals with MetS, higher NLR levels were associated with male gender, older age, lower estimated glomerular filtration rate, and cardiac adverse remodeling.
BackgroundPrevious studies have shown that metabolic syndrome (MetS) is associated with increased systemic inflammation and cardiac mortality in elderly subjects. However, information on the association of inflammation markers with cardiac adverse remodeling is limited in the elderly with MetS. Therefore, we investigated whether the inflammatory marker neutrophil/lymphocyte ratio (NLR) is associated with the cardiac adverse remodeling in Chinese elderly with MetS. MethodsA total of 1,087 hospitalized Chinese elderly (aged >= 65 years) with MetS were collected retrospectively. The cross-sectional data of echocardiography and clinical parameters were compared among quartile NLR groups. ResultsIn the elderly with MetS, higher quartile NLR (>= 3.83) was found to be associated with male gender, older age, lower estimated glomerular filtration rate (eGFR), and cardiac left ventricular (LV) dilatation (all p <0.05). ConclusionHigher NLR is associated with male gender, older age, renal dysfunction, and cardiac adverse remodeling in Chinese elderly with MetS.
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