Related references
Note: Only part of the references are listed.Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes
Xiu Mei Ma et al.
CELL BIOLOGY AND TOXICOLOGY (2023)
NLRP3 inflammasome as a key driver of vascular disease
Masafumi Takahashi
CARDIOVASCULAR RESEARCH (2022)
Small molecule STING inhibition improves myocardial infarction remodeling
Lavinia Rech et al.
LIFE SCIENCES (2022)
A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion
Jingting Qiao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)
The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy
Patrick Kwabena Oduro et al.
ACTA PHARMACEUTICA SINICA B (2022)
Microbial DNA enrichment promotes liver steatosis and fibrosis in the course of non-alcoholic steatohepatitis
Zhenlong Luo et al.
ACTA PHYSIOLOGICA (2022)
IFI16-STING-NF-κB signaling controls exogenous mitochondrion-induced endothelial activation
Shu Li et al.
AMERICAN JOURNAL OF TRANSPLANTATION (2022)
cGAS-STING mediates cytoplasmic mitochondrial-DNA-induced inflammatory signal transduction during accelerated senescence of pancreatic β-cells induced by metabolic stress
Huiqing Hu et al.
FASEB JOURNAL (2022)
The selective STING inhibitor H-151 preserves myocardial function and ameliorates cardiac fibrosis in murine myocardial infarction
Shiyu Hu et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
Mitochondrial damage and activation of the cytosolic DNA sensor cGAS-STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice
Meiling Yan et al.
CELL DEATH DISCOVERY (2022)
Endothelial Cell Phenotype, a Major Determinant of Venous Thrombo-Inflammation
Marion Pilard et al.
FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)
Obesity, Inflammation, and Immune System in Osteoarthritis
Udhaya Nedunchezhiyan et al.
FRONTIERS IN IMMUNOLOGY (2022)
Palmitic acid promotes endothelial-to-mesenchymal transition via activation of the cytosolic DNA-sensing cGAS-STING pathway
Qian Liu et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2022)
Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy
Yang Zhao et al.
CARDIOVASCULAR DRUGS AND THERAPY (2021)
Mitochondrial dysfunction in cardiovascular disease: Current status of translational research/clinical and therapeutic implications
Antonis S. Manolis et al.
MEDICINAL RESEARCH REVIEWS (2021)
Adipose tissue inflammation and metabolic dysfunction in obesity
Tatsuo Kawai et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2021)
Mitochondrial Damage-Induced Innate Immune Activation in Vascular Smooth Muscle Cells Promotes Chronic Kidney Disease-Associated Plaque Vulnerability
Xianjin Bi et al.
ADVANCED SCIENCE (2021)
Activation of Toll-like receptor 7 provides cardioprotection in septic cardiomyopathy-induced systolic dysfunction
Xie Saiyang et al.
CLINICAL AND TRANSLATIONAL MEDICINE (2021)
Vascular smooth muscle cells in atherosclerosis: time for a re-assessment
Mandy O. J. Grootaert et al.
CARDIOVASCULAR RESEARCH (2021)
Pro-Angiogenic Effects of Essential Oil from Perilla frutescens and Its Main Component (Perillaldehyde) on Zebrafish Embryos and Human Umbilical Vein Endothelial Cells
Fei Zhou et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2021)
Balasubramide derivative 3C attenuates atherosclerosis in apolipoprotein E-deficient mice: role of AMPK-STAT1-STING signaling pathway
Dongcheng Cai et al.
Aging-US (2021)
Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation
Yifan Lu et al.
REDOX BIOLOGY (2021)
Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING
Run Fang et al.
IMMUNITY (2021)
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections
Seoyun Yum et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3
Peng Tang et al.
CELL DEATH AND DIFFERENTIATION (2021)
STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases
Phuong Tran Pham et al.
EUROPEAN HEART JOURNAL (2021)
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C
Ting-Ting Chu et al.
NATURE (2021)
STING inhibitors target the cyclic dinucleotide binding pocket
Ze Hong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
Plasmacytoid Dendritic Cells Mediate Myocardial Ischemia/Reperfusion Injury by Secreting Type I Interferons
Lina Lai et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)
Activation of STING Pathway Contributed to Cisplatin-Induced Cardiac Dysfunction via Promoting the Activation of TNF-α-AP-1 Signal Pathway
Lintao Wang et al.
FRONTIERS IN PHARMACOLOGY (2021)
TDP43 Exacerbates Atherosclerosis Progression by Promoting Inflammation and Lipid Uptake of Macrophages
Ning Huangfu et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases
Ming-Ming Hu et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)
Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture
Wei Luo et al.
CIRCULATION (2020)
Neutrophils as regulators of cardiovascular inflammation
Carlos Silvestre-Roig et al.
NATURE REVIEWS CARDIOLOGY (2020)
Reappraising the role of inflammation in heart failure
Luigi Adamo et al.
NATURE REVIEWS CARDIOLOGY (2020)
Cytosolic DNA sensor cGAS plays an essential pathogenetic role in pressure overload-induced heart failure
Dan Hu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)
STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress
Yan Zhang et al.
BIOMEDICINE & PHARMACOTHERAPY (2020)
mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
Long Shuang Huang et al.
IMMUNITY (2020)
TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
Katherine R. Balka et al.
CELL REPORTS (2020)
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
Ekaterina V. Vinogradova et al.
CELL (2020)
Double knockout of Akt2 and AMPK accentuates high fat diet-induced cardiac anomalies through a cGAS-STING-mediated mechanism
Yan Gong et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)
STEEP mediates STING ER exit and activation of signaling
Bao-cun Zhang et al.
NATURE IMMUNOLOGY (2020)
Regulation and Consequences of cGAS Activation by Self-DNA
Christian Zierhut et al.
TRENDS IN CELL BIOLOGY (2020)
C9orf72 in myeloid cells suppresses STING-induced inflammation
Madelyn E. McCauley et al.
NATURE (2020)
Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis
Martin Mollenhauer et al.
SCIENTIFIC REPORTS (2020)
Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs
Christina A. Castellani et al.
GENOME MEDICINE (2020)
Long-Term Cardiovascular Outcomes in Systemic Lupus Erythematosus
Adelina Yafasova et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)
Beclin1 Haploinsufficiency accentuates second-hand smoke exposure-induced myocardial Remodeling and contractile dysfunction through a STING-mediated mechanism
Fangpeng Liu et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)
Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice
Qingqin Xu et al.
LIFE SCIENCES (2020)
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
Hui Yu et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
Acute and chronic remote ischemic conditioning attenuate septic cardiomyopathy, improve cardiac output, protect systemic organs, and improve mortality in a lipopolysaccharide-induced sepsis model
Takashi Honda et al.
BASIC RESEARCH IN CARDIOLOGY (2019)
Inflammation and fibrosis in murine models of heart failure
Lucas Bacmeister et al.
BASIC RESEARCH IN CARDIOLOGY (2019)
Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity
Jiang Dai et al.
CELL (2019)
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
Xiang Gui et al.
NATURE (2019)
Structural basis of STING binding with and phosphorylation by TBK1
Conggang Zhang et al.
NATURE (2019)
cGAS in action: Expanding roles in immunity and inflammation
Andrea Ablasser et al.
SCIENCE (2019)
The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism
Juli Bai et al.
DIABETES (2019)
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1
Baoyu Zhao et al.
NATURE (2019)
Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models
Mona Motwani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
Sabrina L. Ergun et al.
CELL (2019)
STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3
Ning Li et al.
REDOX BIOLOGY (2019)
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis
Ki Wung Chung et al.
CELL METABOLISM (2019)
Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury
Hiroshi Maekawa et al.
CELL REPORTS (2019)
Self-Awareness: Nucleic Acid–Driven Inflammation and the Type I Interferonopathies
Carolina Uggenti et al.
Annual Review of Immunology (2019)
STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis
Yongsheng Yu et al.
JOURNAL OF CLINICAL INVESTIGATION (2019)
Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING
Tony Siu et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis
Dag Leonard et al.
ANNALS OF THE RHEUMATIC DISEASES (2018)
Extracellular DNA and autoimmune diseases
Hantao Lou et al.
CELLULAR & MOLECULAR IMMUNOLOGY (2018)
Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury
Dian J. Cao et al.
CIRCULATION (2018)
Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels
Modi Wang et al.
FUTURE MEDICINAL CHEMISTRY (2018)
RP105 alleviates myocardial ischemia reperfusion injury via inhibiting TLR4/TRIF signaling pathways
Jun Yang et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)
Inhibition of Cyclic GMP-AMP Synthase Using a Novel Antimalarial Drug Derivative in Trex1-Deficient Mice
Jie An et al.
ARTHRITIS & RHEUMATOLOGY (2018)
The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila
Akira Goto et al.
IMMUNITY (2018)
Perillaldehyde prevents the formations of atherosclerotic plaques through recoupling endothelial nitric oxide synthase
Li Yu et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2018)
Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
Gillian Dunphy et al.
MOLECULAR CELL (2018)
Parkin and PINK1 mitigate STING-induced inflammation
Danielle A. Sliter et al.
NATURE (2018)
Targeting STING with covalent small-molecule inhibitors
Simone M. Haag et al.
NATURE (2018)
Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice
Xianjun Luo et al.
GASTROENTEROLOGY (2018)
Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
Folkert Steinhagen et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2018)
Ablation of Interferon Regulatory Factor 3 Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice
Hui Liu et al.
HYPERTENSION (2017)
Palmitic acid dysregulates the Hippo-YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS-STING-IRF3 signaling mechanism
Liangshuai Yuan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
A noncanonical function of cGAMP in inflammasome priming and activation
Karen V. Swanson et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2017)
STING-associated vasculopathy develops independently of IRF3 in mice
James D. Warner et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2017)
NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway
Run Fang et al.
JOURNAL OF IMMUNOLOGY (2017)
IRF3 and type I interferons fuel a fatal response to myocardial infarction
Kevin R. King et al.
NATURE MEDICINE (2017)
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice
Jessica Vincent et al.
NATURE COMMUNICATIONS (2017)
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3
Moritz M. Gaidt et al.
CELL (2017)
Role of free fatty acids in endothelial dysfunction
Arijit Ghosh et al.
JOURNAL OF BIOMEDICAL SCIENCE (2017)
STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity
Yun Mao et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)
Vascular inflammation and media calcification are already present in early stages of chronic kidney disease
Kerstin Benz et al.
CARDIOVASCULAR PATHOLOGY (2017)
Nitrated fatty acids suppress angiotensin II-mediated fibrotic remodelling and atrial fibrillation
Tanja K. Rudolph et al.
CARDIOVASCULAR RESEARCH (2016)
Nitro-oleic acid inhibits vascular endothelial inflammatory responses and the endothelial-mesenchymal transition
Gabriela Ambrozova et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2016)
Lipotoxicity in obesity and diabetes-related cardiac dysfunction
Igor Zlobine et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2016)
Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins
Baoyu Zhao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
An integrative view of cisplatin-induced renal and cardiac toxicities: Molecular mechanisms, current treatment challenges and potential protective measures
George J. Dugbartey et al.
TOXICOLOGY (2016)
Activation of STING requires palmitoylation at the Golgi
Kojiro Mukai et al.
NATURE COMMUNICATIONS (2016)
NLRP3 at the interface of metabolism and inflammation
Moritz Haneklaus et al.
IMMUNOLOGICAL REVIEWS (2015)
Cutting Edge: Antimalarial Drugs Inhibit IFN-β Production through Blockade of Cyclic GMP-AMP Synthase-DNA Interaction
Jie An et al.
JOURNAL OF IMMUNOLOGY (2015)
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
Daxing Gao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Protective Effects of 10-nitro-oleic Acid in a Hypoxia-Induced Murine Model of Pulmonary Hypertension
Anna Klinke et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)
Inflammation and Cardiovascular Disease: From Pathogenesis to Therapeutic Target
Enrica Golia et al.
CURRENT ATHEROSCLEROSIS REPORTS (2014)
Intrinsic Self-DNA Triggers Inflammatory Disease Dependent on STING
Jeonghyun Ahn et al.
JOURNAL OF IMMUNOLOGY (2014)
FAM3A promotes vascular smooth muscle cell proliferation and migration and exacerbates neointima formation in rat artery after balloon injury
Shi Jia et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)
Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF-κB Activation through TBK1
Takayuki Abe et al.
JOURNAL OF VIROLOGY (2014)
Mortality and years of potential life loss in systemic lupus erythematosus: a population-based cohort study
K. Lerang et al.
LUPUS (2014)
The inflammatory response in myocardial injury, repair, and remodelling
Nikolaos G. Frangogiannis
NATURE REVIEWS CARDIOLOGY (2014)
Activated STING in a Vascular and Pulmonary Syndrome
Y. Liu et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Cyclic [G(2′,5′) pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
Pu Gao et al.
CELL (2013)
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
Andrea Ablasser et al.
NATURE (2013)
Structural mechanism of cytosolic DNA sensing by cGAS
Filiz Civril et al.
NATURE (2013)
The Beneficial Effect of Suramin on Monocrotaline-Induced Pulmonary Hypertension in Rats
Mohamed Izikki et al.
PLOS ONE (2013)
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Lijun Sun et al.
SCIENCE (2013)
STING manifests self DNA-dependent inflammatory disease
Jeonghyun Ahn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Cisplatin-induced cardiotoxicity Mechanisms and cardioprotective strategies
El-Sayed E. El-Awady et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2011)
STING is a direct innate immune sensor of cyclic di-GMP
Dara L. Burdette et al.
NATURE (2011)
Nitro-Fatty Acid Inhibition of Neointima Formation After Endoluminal Vessel Injury
Marsha P. Cole et al.
CIRCULATION RESEARCH (2009)
Introducing a new entity: chemotherapy-induced arrhythmia
Maya Guglin et al.
EUROPACE (2009)
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Hiroki Ishikawa et al.
NATURE (2009)
Suppressive oligodeoxynucleotides inhibit atherosclerosis in ApoE-/- mice through modulation of Th1/Th2 balance
Xiang Cheng et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2008)
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus
Min Ae Lee-Kirsch et al.
NATURE GENETICS (2007)
Activation of cardiac endothelium as a compensatory component in endotoxin-induced cardiomyopathy - Role of endothelin, prostaglandins, and nitric oxide
A Mebazaa et al.
CIRCULATION (2001)
Share Paper
