Developmental depression-to-facilitation shift controls excitation-inhibition balance

Changes in the short-term dynamics of excitatory synapses over development have been observed throughout cortex, but their purpose and consequences remain unclear. Here, we propose that developmental changes in synaptic dynamics buffer the effect of slow inhibitory long-term plasticity, allowing for continuously stable neural activity. Using computational modeling we demonstrate that early in development excitatory short-term depression quickly stabilises neural activity, even in the face of strong, unbalanced excitation. We introduce a model of the commonly observed developmental shift from depression to facilitation and show that neural activity remains stable throughout development, while inhibitory synaptic plasticity slowly balances excitation, consistent with experimental observations. Our model predicts changes in the input responses from phasic to phasic-and-tonic and more precise spike timings. We also observe a gradual emergence of short-lasting memory traces governed by short-term plasticity development. We conclude that the developmental depression-to-facilitation shift may control excitation-inhibition balance throughout development with important functional consequences. Using computational modelling this study proposes that the commonly observed depression-to-facilitation shift across development controls excitation-inhibition balance in the brain.

Automated summary

This article investigates the effects of developmental changes in the short-term dynamics of excitatory synapses on neural activity stability. Using computational modeling, it is found that early in development, short-term depression of excitatory synapses stabilizes neural activity, while inhibitory synaptic plasticity balances excitation throughout development. The study also predicts changes in input responses and the emergence of short-lasting memory traces.