4.7 Article

miR204 potentially promotes non-alcoholic fatty liver disease by inhibition of cpt1a in mouse hepatocytes

Related references

Note: Only part of the references are listed.
Article Endocrinology & Metabolism

Hepatic CPT1A Facilitates Liver Adipose Cross Talk via Induction of FGF21 in Mice

Wei Sun et al.

Summary: This study reveals that deficiency of hepatic CPT1A protects against high-fat diet-induced liver damage and enhances adipose browning. Activation of the peroxisome proliferator-activated receptor alpha-fibroblast growth factor 21 (FGF21) axis in the liver contributes to the improved metabolic state.

DIABETES (2022)

Article Gastroenterology & Hepatology

Activated Natural Killer Cell Promotes Nonalcoholic Steatohepatitis Through Mediating JAK/STAT Pathway

Feixue Wang et al.

Summary: Activated NK cells in the liver promote NASH development by releasing pro-inflammatory cytokines and enhancing NASH progression through the cytokine-JAK-STAT1/3 axis. Modulation of NK cells may serve as a potential therapeutic strategy for NASH.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Gastroenterology & Hepatology

miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder

Lei Fan et al.

Summary: miR-552-3p has the ability to improve hepatic glycolipid metabolism by modulating the transcriptional activities of LXR alpha and FXR in the nucleus, which provides a potential therapeutic target for the treatment of glycolipid metabolic disease, as shown through various molecular and clinical studies.

JOURNAL OF HEPATOLOGY (2021)

Article Oncology

MicroRNA-204 plays a role as a tumor suppressor in Newcastle disease virus-induced oncolysis in lung cancer A549 cells

Ying Liang et al.

Summary: The study revealed that miR-204 plays a critical role in NDV-induced oncolysis in lung cancer cells by regulating the Caspase-3 and Bax pathway. This suggests the potential of utilizing miRs to enhance the oncolytic potency of NDV, with miR-204 identified as a tumor suppressor in NDV-induced oncolysis of lung cancer cells.

ONCOLOGY LETTERS (2021)

Article Biochemistry & Molecular Biology

Isocitrate dehydrogenase 2 deficiency aggravates prolonged high-fat diet intake-induced hypertension

Mi Ra Noh et al.

REDOX BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Genetic deletion of miR-204 improves glycemic control despite obesity in db/db mice

Ravinder Reddy Gaddam et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Review Pharmacology & Pharmacy

AMPK-Mediated Regulation of Lipid Metabolism by Phosphorylation

Qi Wang et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2018)

Article Urology & Nephrology

Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin

Mardiana Lee et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Article Biochemistry & Molecular Biology

Isocitrate dehydrogenase 2 deficiency induces endothelial inflammation via p66sh-mediated mitochondrial oxidative stress

Su-jeong Choi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Peripheral Vascular Disease

Nicotinamide nucleotide transhydrogenase activity impacts mitochondrial redox balance and the development of hypertension in mice

Igor Leskov et al.

JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION (2017)

Review Biochemistry & Molecular Biology

Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

Jasvinder Singh Bhatti et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Article Medicine, General & Internal

Obesity and inflammation: the linking mechanism and the complications

Mohammed S. Ellulu et al.

ARCHIVES OF MEDICAL SCIENCE (2017)

Article Biochemistry & Molecular Biology

IDH2 deficiency impairs mitochondrial function in endothelial cells and endothelium-dependent vasomotor function

Jung-Bum Park et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Biochemistry & Molecular Biology

Increased obesity resistance and insulin sensitivity in mice lacking the isocitrate dehydrogenase 2 gene

Su Jeong Lee et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Multidisciplinary Sciences

Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium

Jianhai Du et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Immunology

Macrophage cytokines: involvement in immunity and infectious diseases

Guillermo Arango Duque et al.

FRONTIERS IN IMMUNOLOGY (2014)

Review Nutrition & Dietetics

Mitochondrial-associated metabolic disorders: foundations, pathologies and recent progress

Joseph McInnes

NUTRITION & METABOLISM (2013)

Article Multidisciplinary Sciences

MicroRNA Expression in Alpha and Beta Cells of Human Pancreatic Islets

Dagmar Klein et al.

PLOS ONE (2013)

Review Cell Biology

MicroRNAs in metabolism and metabolic disorders

Veerle Rottiers et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Multidisciplinary Sciences

MicroRNAs 103 and 107 regulate insulin sensitivity

Mirko Trajkovski et al.

NATURE (2011)

Review Pharmacology & Pharmacy

Role of microRNAs in Non-Alcoholic Steatohepatitis

Onpan Cheung et al.

CURRENT PHARMACEUTICAL DESIGN (2010)

Article Cell Biology

A comprehensive definition for metabolic syndrome

Paul L. Huang

DISEASE MODELS & MECHANISMS (2009)

Review Cell Biology

MicroRNAs:: A new class of regulatory genes affecting metabolism

Jan Krutzfeldt et al.

CELL METABOLISM (2006)

Article Biochemistry & Molecular Biology

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells

L Bordone et al.

PLOS BIOLOGY (2006)