Related references
Note: Only part of the references are listed.Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors
Mahmoud A. El Hassab et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2022)
Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies
Reda G. Yousef et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2022)
Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies
Mohammed S. Taghour et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2022)
Design, synthesis and structure-activity evaluation of novel 2-pyridone-based inhibitors of α-synuclein aggregation with potentially improved BBB permeability
Alejandro Mahia et al.
BIOORGANIC CHEMISTRY (2021)
2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease
Katrina L. Forrestall et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2021)
Pyridones in drug discovery: Recent advances
Yun Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)
Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer
Fatema Tuz Zahra et al.
CANCERS (2021)
Graphene oxide and its nanocomposites with EDTA or chitosan induce apoptosis in MCF-7 human breast cancer
Ahmed S. Doghish et al.
RSC ADVANCES (2021)
Design, synthesis, anticancer evaluation, and molecular modelling studies of novel tolmetin derivatives as potential VEGFR-2 inhibitors and apoptosis inducers
Asmaa E. Kassab et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)
In silico identification of novel SARS-COV-2 2′-O-methyltransferase (nsp16) inhibitors: structure-based virtual screening, molecular dynamics simulation and MM-PBSA approaches
Mahmoud A. El Hassab et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)
Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants
Bryan D. Smith et al.
CANCER CELL (2019)
Recent advances in the synthetic and medicinal perspective of quinolones: A review
Prashant Dhiman et al.
BIOORGANIC CHEMISTRY (2019)
Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases
Jordi Bach et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Targeted therapeutic options and future perspectives for HER2-positive breast cancer
Jiani Wang et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)
Resistance to EGFR inhibitors in non-small cell lung cancer: Clinical management and future perspectives
Chiara Tomasello et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2018)
A Novel Synthesis of Highly Functionalized Pyridines by a One-Pot, Three-Component Tandem Reaction of Aldehydes, Malononitrile and N-Alkyl-2-cyanoacetamides under Microwave Irradiation
Ramadan Ahmed Mekheimer et al.
MOLECULES (2018)
Duvelisib, a novel oral dual inhibitor of PI3K-δ,γ, is clinically active in advanced hematologic malignancies
Ian W. Flinn et al.
BLOOD (2018)
Discovery of novel dual VEGFR2 and Src inhibitors using a multistep virtual screening approach
Shangying Chen et al.
FUTURE MEDICINAL CHEMISTRY (2017)
Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial
Miguel Martin et al.
LANCET ONCOLOGY (2017)
Preclinical Evidence That Trametinib Enhances the Response to Antiangiogenic Tyrosine Kinase Inhibitors in Renal Cell Carcinoma
Victoria L. Bridgeman et al.
MOLECULAR CANCER THERAPEUTICS (2016)
Synthesis and Cytotoxic Effect of Some Novel 1,2-Dihydropyridin-3-carbonitrile and Nicotinonitrile Derivatives
Eman M. Flefel et al.
MOLECULES (2016)
Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window
Joachim Rudolph et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Design, synthesis and biological evaluation of indazole-pyrimidine based derivatives as anticancer agents with anti-angiogenic and antiproliferative activities
Nevine M. Y. Elsayed et al.
MEDCHEMCOMM (2016)
Targeting HER2 for the Treatment of Breast Cancer
Mothaffar F. Rimawi et al.
ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)
Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition
Wataru Hamaguchi et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Global Cancer Statistics, 2012
Lindsey A. Torre et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2015)
DOCKTITE-A Highly Versatile Step-by-Step Workflow for Covalent Docking and Virtual Screening in the Molecular Operating Environment
Christoph Scholz et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2015)
Palbociclib in Hormone-Receptor-Positive Advanced Breast Cancer
Nicholas C. Turner et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells
B. Chu et al.
CELL DEATH & DISEASE (2015)
g_mmpbsa-A GROMACS Tool for High-Throughput MM-PBSA Calculations
Rashmi Kumari et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2014)
One Pot Synthesis of Novel Cyanopyridones as an Intermediate of Bioactive Pyrido[2,3-d]Pyrimidines
Taslimahemad T. Khatri et al.
JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE (2014)
PROPERTIES AND SYNTHESIS OF MILRINONE
Jelena M. Mirkovic et al.
HEMIJSKA INDUSTRIJA (2013)
The important roles of RET, VEGFR2 and the RAF/MEK/ERK pathway in cancer treatment with sorafenib
Wei-feng Mao et al.
ACTA PHARMACOLOGICA SINICA (2012)
Synthesis, Anticancer Activity and Radiosensitizing Evaluation of Some New 2-Pyridone Derivatives
M. S. El-Said et al.
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH (2012)
Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles
Yuusuke Tamura et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases
David P. Kodack et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: Hit to lead
Tony Siu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Epidermal Growth Factor Receptor in Triple-Negative and Basal-Like Breast Cancer Promising Clinical Target or Only a Marker?
Monika L. Burness et al.
CANCER JOURNAL (2010)
Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore
Fraser F. Fleming et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
The unique role of halogen substituents in the design of modern agrochemicals
Peter Jeschke
PEST MANAGEMENT SCIENCE (2010)
Medicinal Chemistry and the Molecular Operating Environment (MOE): Application of QSAR and Molecular Docking to Drug Discovery
Santiago Vilar et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2008)
Novel scaffold for cathepsin K inhibitors
Naoki Teno et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
The role of fluorine in medicinal chemistry
Poonam Shah et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2007)
Novel pirfenidone analogues: Synthesis of pyridin-2-ones for the treatment of pulmonary fibrosis
Yousry A. Ammar et al.
ARCHIV DER PHARMAZIE (2006)
Modern synthetic methods for fluorine-substituted target molecules
M Shimizu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Cyanoacetan intermediates in heterocyclic synthesis. Part 1: A facile synthesis of polysubstituted and condensed pyridones
YA Ammar et al.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY (2004)
Opportunities for cancer epidemiology in developing countries
T Rastogi et al.
NATURE REVIEWS CANCER (2004)
Achieving selectivity between highly homologous tyrosine kinases: a novel selective erbB2 inhibitor
SK Bhattacharya et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Photochemical preparation of a pyridone containing tetracycle: A Jak protein kinase inhibitor
JE Thompson et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)
Receptor tyrosine kinases as target for anti-cancer therapy
S Brunelleschi et al.
CURRENT PHARMACEUTICAL DESIGN (2002)
Nuclear localization of EGF receptor and its potential new role as a transcription factor
SY Lin et al.
NATURE CELL BIOLOGY (2001)
Share Paper
