Journal
PHARMACEUTICALS
Volume 15, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/ph15101258
Keywords
obesity; hyperlipidic diet; inflammation; Swiss mice
Categories
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES-Brazil [001]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq [426172/2018-3]
- Universidade Federal de Mato Grosso do Sul-UFMS [15/2022]
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This study evaluated the efficacy of Baccharis trimera infusion on high-fat diet-induced metabolic disorders and macrophages activation. The results showed that B. trimera prevented the development of obesity and associated comorbidities, as well as the activation of macrophages. This study validates the popular use of this plant tea.
The aim of this study is to evaluate the efficacy of Baccharis trimera infusion on high-fat diet-induced metabolic disorders in mice and macrophages activation. This study evaluated obesity, insulin resistance, dyslipidemia and hepatic steatosis induced by a high-fat diet in Swiss mice. Cellular parameters in macrophages, such as cell viability (MTT), the production and release of nitric oxide (NO) and hydrogen peroxide (H2O2), cell spreading, cell adhesion and phagocytosis were determined. Our results showed that treatment with B. trimera prevented the mentioned conditions, except for the production of hydrogen peroxide. B. trimera prevented the development of obesity and associated comorbidities, as well as activation of macrophages. In conclusion, B. trimera is able to prevent obesity and metabolic disorders and macrophages activation, minimizing inflammation and validating the popular use of this plant tea.
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