Journal
PHARMACEUTICALS
Volume 15, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ph15081009
Keywords
Strecker reaction; Mannich reaction; Petasis reaction; Povarov reaction; Hantzsch dihydropyridine synthesis; Hantzsch pyrrole synthesis; Asinger reaction; Passerini reaction; Ugi reaction; Gewald reaction
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Funding
- Ministerio de Ciencia e Innovacion [RTI2018097662-B-I00, PID2021-124983OB-I00]
- Mexican National Science and Technology Council [766584]
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Multicomponent reactions have been widely employed in compound library construction and offer significant advantages in target-oriented synthesis.
Multicomponent reactions 9i.e., those that engage three or more starting materials to form a product that contains significant fragments of all of them), have been widely employed in the construction of compound libraries, especially in the context of diversity-oriented synthesis. While relatively less exploited, their use in target-oriented synthesis offers significant advantages in terms of synthetic efficiency. This review provides a critical summary of the use of multicomponent reactions for the preparation of active pharmaceutical principles.
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