Journal
JOURNAL OF PERSONALIZED MEDICINE
Volume 12, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/jpm12081323
Keywords
Mass General Brigham Biobank; biobank; biorepository; personalized medicine; precision medicine; translational research; research operations
Funding
- NIAMS [P30 AR070253]
- NHGRI [U01 HG008685, 5UM1HG008895]
- IBM
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The Mass General Brigham Biobank is a large repository of biospecimens and data aimed at supporting translational research on disease phenotypes. It has enrolled over 135,000 participants, generated genomic data on more than 65,000 participants, and served numerous institutional studies. However, it faces challenges in terms of funding sustainability, integration into clinical workflows, and promoting diversity and equity in research resources.
The Mass General Brigham Biobank (formerly Partners HealthCare Biobank) is a large repository of biospecimens and data linked to extensive electronic health record data and survey data. Its objective is to support and enable translational research focused on genomic, environmental, biomarker and family history associations with disease phenotypes. The Biobank has enrolled more than 135,000 participants, generated genomic data on more than 65,000 of its participants, distributed approximately 153,000 biospecimens, and served close to 450 institutional studies with biospecimens or data. Although the Biobank has been successful, based on some measures of output, this has required substantial institutional investment. In addition, several challenges are ongoing, including: (1) developing a sustainable cost model that doesn't rely as heavily on institutional funding; (2) integrating Biobank operations into clinical workflows; and (3) building a research resource that is diverse and promotes equity in research. Here, we describe the evolution of the Biobank and highlight key lessons learned that may inform other efforts to build biobanking efforts in health system contexts.
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