Journal
JOURNAL OF PERSONALIZED MEDICINE
Volume 12, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/jpm12101610
Keywords
claims data; dysmenorrhea; ischemic heart disease; nested case-control study; retrospective cohort study
Funding
- Ministry of Health and Welfare Clinical Trial Center [MOHW110-TDU-B-212-124004]
- Ministry of Science and Technology [MOST 110-2321-B-039-003]
- China Medical University Hospital [DMR-111-228]
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The awareness on the relationship between dysmenorrhea and ischemic heart disease (IHD) in women is insufficient. This study utilized a large database in Taiwan to evaluate this relationship. The results showed that women with dysmenorrhea have a higher risk of developing IHD, especially for older patients and patients with comorbidity such as hypertension and arrhythmia.
The awareness on ischemic heart disease (IHD) in women with dysmenorrhea is insufficient. We utilized the National Health Insurance Research Database (NHIRD) of Taiwan to evaluate this relationship. From the claims data, we established a cohort of women aged 15-50 years with primary dysmenorrhea diagnosed from 2000 to 2008 (n = 18,455) and a comparison cohort (n = 36,910) without dysmenorrhea, frequency matched by age and diagnosis date. Both cohorts were followed until the end of 2013 to assess IHD events. With 75% of study population aged 15-29 years, the incidence of IHD was greater in the dysmenorrheal cohort than in the comparison cohort (1.93 versus 1.18 per 10,000 person-years), with an adjusted hazard ratio of 1.60 (95% confidence interval [CI] = 1.38-1.85). The incidence increased with age and the rate of increase was greater in the dysmenorrheal cohort than the comparison cohort. Nested case-control analysis in the dysmenorrhea cohort showed that IHD risk was also associated with hypertension and arrhythmia, with adjusted odds ratios of 2.50 (95% CI = 1.64-3.81) and 3.30 (95% CI = 2.25-4.86), respectively. Women with dysmenorrhea are at a higher risk of developing IHD, particularly for older patients and patients with comorbidity.
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