Journal
ISCIENCE
Volume 25, Issue 11, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.isci.2022.105283
Keywords
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Categories
Funding
- National Natural Science Foundation of China of China
- Fundamental Research Funds for the Central Universities of Central South University
- Hunan Provincial Natural Scientific Foundation
- Scientific Research Project of Hunan Provincial Health and Family Planning Commission
- [82173911]
- [81973406]
- [2022ZZTS0954]
- [2022ZZTS0243]
- [2019JJ50849]
- [2020JJ4823]
- [2022JJ80109]
- [202113050843]
- [CPA-Z05-ZC-2021-002]
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Cardiotoxicity caused by anticancer drugs can pose life-threatening risks or long-term morbidity by interfering with optimal treatment. The heart is a complex organ composed of cardiomyocytes and non-cardiomyocytes, with non-cardiomyocytes playing an increasingly recognized dynamic and essential role in drug-induced cardiotoxicity. This review provides an overview of the involvement of non-cardiomyocytes in cardiotoxicity, including direct damage, paracrine-induced cardiomyocyte injury, transient cell-induced myocardial inflammation, and protective agents targeting non-cardiomyocytes.
Cardiotoxicity induced by anticancer drugs interferes with the continuation of optimal treatment, inducing life-threatening risks or leading to long-term morbidity. The heart is a complex pluricellular organ comprised of cardiomyocytes and non-cardiomyocytes. Although the study of these cell populations has been often focusing on cardiomyocytes, the contributions of non-cardiomyocytes to development and disease are increasingly being appreciated as both dynamic and essential. This review summarized the role of non-cardiomyocytes in anticancer drug-induced cardiotoxicity, including the mechanism of direct damage to resident non-cardiomyocytes, cardiomyocytes injury caused by paracrine modality, myocardial inflammation induced by transient cell populations and the protective agents that focused on non-cardiomyocytes.
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