Journal
JOURNAL OF MICROBIOLOGY
Volume 54, Issue 3, Pages 149-169Publisher
MICROBIOLOGICAL SOCIETY KOREA
DOI: 10.1007/s12275-016-5514-0
Keywords
host response; fungal infection; adhesion; morphogenesis; biofilm; fungal-bacterial interactions
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Funding
- Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI)
- Deutsche Forschungsgemeinschaft [DFG SPP 1580, Hu 528/17, SFB/TR 124]
- European Union (OPATHY-Marie Sklodowska-Curie Actions - European Training Networks [ETN]
- Center for Sepsis Control and Care (CSCC) [BMBF 01EO1002]
- InfectERA Program (FunComPath) [BMBF 031L0001A]
- International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
- Jena School of Microbial Communication (JSMC)
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The interaction between Candida albicans and its host cells is characterized by a complex interplay between the expression of fungal virulence factors, which results in adherence, invasion and cell damage, and the host immune system, which responds by secreting proinflammatory cytokines, activating antimicrobial activities and killing the fungal pathogen. In this review we describe this interplay by taking a closer look at how C. albicans pathogenicity is induced and executed, how the host responds in order to prevent and clear an infection, and which mechanisms C. albicans has evolved to bypass these immune responses to avoid clearance. Furthermore, we review studies that show how the presence of other microorganisms affects this interplay.
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