Interplay between the m6A Epitranscriptome and Tumor Metabolism: Mechanisms and Therapeutic Implications

N-6-methyladenosine (m(6)A) modification of messenger RNA (mRNA) influences the stability and translation of the transcripts into functional proteins. Recent studies reveal the role of m(6)A modifications in regulating the metabolism of basic biomolecules such as glucose, lipids and amino acids. Such mechanisms are not only important for physiological functions of normal cells but also prove to be pivotal for the pathogenesis of cancers by driving dysregulated metabolism. M(6)A writers, readers and erasers function co-operatively to promote aberrant glucose, lipid and amino acid metabolism in cancer cells, which in turn support increased proliferative and metastatic potential. Better understanding of the relationship between m(6)A and metabolism in malignancy may unravel novel therapeutic targets as well as biomarkers in cancer. In this review, we summarize the recent evidence demonstrating the interplay between m(6)A modification and cancer metabolism and their therapeutic implications.

Automated summary

N-6-methyladenosine (m(6)A) modification of mRNA has a significant impact on stability and translation into proteins. Recent studies have revealed the role of m(6)A modifications in regulating basic biomolecule metabolism and their importance for both normal cell functions and cancer pathogenesis. The interplay between m(6)A modification and cancer metabolism has implications for identifying therapeutic targets and biomarkers for cancer.