Journal
BIOMEDICINES
Volume 10, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines10102556
Keywords
idiopathic interstitial pneumonias; leanness; shortness of breath; severity of illness
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Funding
- JSPS KAKENHI [21H04302, 19H03984, 19K22821, 22K19760]
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This study investigated the factors that cause a decrease in the percent of the predicted value of a 6-minute walk distance (%6MWD) in idiopathic pulmonary fibrosis (IPF) and idiopathic pleuroparenchymal fibroelastosis (IPPFE). The results suggest that leanness, shortness of breath, and severity of illness are the most important factors that determine exercise tolerance, regardless of disease entity in IPF and IPPFE.
Background: In idiopathic pulmonary fibrosis (IPF), 6-minute walking distance (6MWD) is an independent factor for mortality. Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare disease with physical features such as emaciation, but the relationship between IPPFE and 6MWD is unclear. In this study, we investigated the factors that cause a decrease in the percent of the predicted value of a 6-minute walk distance (%6MWD), including the disease entities, IPF and IPPFE. Methods: This study included 100 patients (IPF: 75 patients, IPPFE: 25 patients, age: 73.5 +/- 7.2 years, sex: 73 males) who visited the rehabilitation department. Patients with a %6MWD >= 80% were assigned to the normal group (n = 54), and patients with a %6MWD < 80% were assigned to the decreased group (n = 46). The items showing a significant difference between groups were used as independent variables, after the consideration of multicollinearity, for a logistic analysis where %6MWD < 80% was used as the dependent variable. Results: The 6MWD results show that there was no significant difference between IPF and IPPFE in the absolute value of 6MWD and in the number of people with 6MWD >= 250 m, but when 6MWD was compared with %6MWD, the IPPFE group showed a significantly lower value than the IPF group (p = 0.013). Logistic regression analysis showed that only BMI (p = 0.032), GAP index (p = 0.043), and mMRC (p = 0.026) were factors that caused a decrease in %6MWD in 100 patients. Conclusion: The results suggest that leanness, shortness of breath and severity of illness are the most important factors that determine exercise tolerance, regardless of disease entity in IPF and IPPFE.
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