Journal
BIOMEDICINES
Volume 10, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines10092183
Keywords
spreading depolarization; intracerebral micro-injury; basolateral amygdala; centromedial amygdala
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Funding
- Russian Science Foundation [RSF 22-15-00327]
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The study demonstrates that the amygdala has different susceptibilities to SD, with the basolateral (BLA) region more prone to SD compared to the centromedial (CMA) region. The spatiotemporal features of SD triggered in the amygdala show diverse propagation patterns to the cortex.
Spreading depolarization (SD), a self-propagated wave of transient depolarization, regularly occurs in the cortex after acute brain insults and is now referred as an important diagnostic and therapeutic target in patients with acute brain injury. Here, we show that the amygdala, the limbic structure responsible for post-injury neuropsychological symptoms, exhibits strong regional heterogeneity in vulnerability to SD with high susceptibility of its basolateral (BLA) region and resilience of its centromedial (CMA) region to triggering SD by acute focal damage. The BLA micro-injury elicited SD twice as often compared with identical injury of the CMA region (71% vs. 33%). Spatiotemporal features of SDs triggered in the amygdala indicated diverse patterns of the SD propagation to the cortex. Our results suggest that even relatively small cerebral structures can exhibit regional gradients in their susceptibility to SD and the heterogeneity may contribute to the generation of complex SD patterns in the injured brain.
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