Irisin Is Related to Non-Alcoholic Fatty Liver Disease (NAFLD)

Review Biochemistry & Molecular Biology

Irisin, A Mediator of Muscle Crosstalk with Other Organs: From Metabolism Regulation to Protective and Regenerative Effects

Sedigheh Momenzadeh et al.

Summary: Physical exercise is a therapeutic strategy for certain complications, and irisin, a peptide produced during exercise, has been found to have various effects in different tissues.

CURRENT PROTEIN & PEPTIDE SCIENCE (2022)

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Review Urology & Nephrology

Circulating irisin level in chronic kidney disease patients: a systematic review and meta-analysis

Wenyuan Gan et al.

Summary: This study found that circulating irisin levels were decreased in patients with chronic kidney disease, and were lower in dialysis patients than in non-dialysis patients.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2022)

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Review Biochemistry & Molecular Biology

FNDC5/Irisin: Physiology and Pathophysiology

Rashid Waseem et al.

Summary: A sedentary lifestyle increases the risk of various diseases, while physical exercise reduces these risks. Irisin, a hormone induced by exercise, plays a crucial role in connecting muscles and other tissues and has beneficial effects on fat cells, metabolic processes, bone metabolism, and the nervous system. It also has a role in cancer development and may act via specific integrin receptors. Past research has identified irisin as a potential therapeutic agent for metabolic-related and other diseases.

MOLECULES (2022)

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Article Medicine, General & Internal

Crosstalk between Irisin Levels, Liver Fibrogenesis and Liver Damage in Non-Obese, Non-Diabetic Individuals with Non-Alcoholic Fatty Liver Disease

Angelo Armandi et al.

Summary: This study found that circulating irisin levels in non-diabetic, non-obese patients with NAFLD are associated with fibrosis and severity of liver damage.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Medicine, General & Internal

Non-Alcoholic Fatty Liver Disease and Risk of Macro- and Microvascular Complications in Patients with Type 2 Diabetes

Alessandro Mantovani et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a common hepatic manifestation of metabolic syndrome and is strongly associated with cardiovascular disease. It is also independently associated with microvascular conditions such as chronic kidney disease and neuropathy.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Medicine, General & Internal

Diagnostic Modalities of Non-Alcoholic Fatty Liver Disease: From Biochemical Biomarkers to Multi-Omics Non-Invasive Approaches

Eirini Martinou et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, with increasing prevalence. Early diagnosis and accurate evaluation of fibrosis risk are crucial for managing high-risk patients. Although liver biopsy is currently the gold standard, non-invasive tests are rapidly progressing.

DIAGNOSTICS (2022)

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Article Medicine, General & Internal

The Coexistence of Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus

Marcin Kosmalski et al.

Summary: NAFLD and T2DM are closely related, with common risk factors and pathogenesis. Understanding the coexistence of NAFLD and T2DM can help prevent the occurrence of other diseases and improve quality of life.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Endocrinology & Metabolism

Recent Epidemiology and Risk Factors of Nonalcoholic Fatty Liver Disease

Youn Huh et al.

Summary: Due to the global obesity epidemic, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased in Korea. Genetic, demographic, environmental, and clinical factors contribute to the development of NAFLD. Risk factors for NAFLD include obesity, advancing age, inadequate exercise, and sleep duration. Insulin resistance, type 2 diabetes, metabolic syndrome, and sarcopenia are closely associated with NAFLD. Early assessment and prevention are crucial to address the rising incidence and burden of NAFLD and its complications.

JOURNAL OF OBESITY & METABOLIC SYNDROME (2022)

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Review Biochemistry & Molecular Biology

NAFLD: Mechanisms, Treatments, and Biomarkers

Fatiha Nassir

Summary: Nonalcoholic fatty liver disease (NAFLD), also known as metabolic-associated fatty liver disease (MAFLD), is a common liver disease worldwide that is closely linked to the obesity epidemic. Currently, there is no specific pharmacological treatment available for NAFLD due to incomplete understanding of its mechanisms, lack of accurate and inexpensive imaging tools, and inadequate non-invasive biomarkers. NAFLD can lead to metabolic-associated steatohepatitis (NASH), liver fibrosis, and hepatocellular carcinoma.

BIOMOLECULES (2022)

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Review Biochemistry & Molecular Biology

The potential role of FNDC5/irisin in various liver diseases: awakening the sleeping beauties

Xiaoyu Wang et al.

Summary: In this review, the structure-function relationship of FNDC5/irisin is discussed, along with a comprehensive summary of its pathogenic roles and therapeutic applications in liver diseases. The underlying mechanisms and signaling pathways are also highlighted.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2022)

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Article Pediatrics

Relation of serum irisin levels to obesity and non-alcoholic fatty liver disease

Gokcen Ulualan et al.

Summary: The study found that serum irisin levels are lower in obese children and negatively correlated with body fat accumulation. In NAFLD patients, irisin levels may be related to fatty liver and decrease with liver damage.

TURKISH JOURNAL OF PEDIATRICS (2022)

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Review Medicine, General & Internal

Nonalcoholic Fatty Liver Disease: Could It Be the Next Medical Tsunami?

Priyanka Bhandari et al.

Summary: This review article provides insights into the epidemiology, pathophysiology, evaluation, and management of nonalcoholic fatty liver disease (NAFLD), aiming to raise awareness of this disease process.

CUREUS JOURNAL OF MEDICAL SCIENCE (2022)

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Review Cardiac & Cardiovascular Systems

NAFLD and cardiovascular diseases: a clinical review

Philipp Kasper et al.

Summary: NAFLD, the most common chronic liver disease in Western countries, is closely associated with metabolic comorbidities and poses a significant risk for cardiovascular disease development, especially in patients with progressive forms of the disease and those with concurrent type 2 diabetes.

CLINICAL RESEARCH IN CARDIOLOGY (2021)

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Review Endocrinology & Metabolism

NAFLDin type 2 diabetes mellitus: Still many challenging questions

Simona Cernea et al.

Summary: In patients with type 2 diabetes, the prevalence of non-alcoholic fatty liver disease is double that of the general population, increasing the risks of liver-related morbidity and mortality, as well as other systemic consequences like cardiovascular disease and chronic kidney disease.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2021)

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Review Endocrinology & Metabolism

Progress and Challenges in the Biology of FNDC5 and Irisin

Steffen Maak et al.

Summary: The transmembrane protein FNDC5 was discovered in 2002 and later identified to be expressed in skeletal muscle, heart, and brain. A study in 2012 proposed that skeletal muscle FNDC5, when cleaved in response to exercise, could induce browning in white adipose tissue, leading to the release of irisin. More than 1000 papers have since been published exploring the roles of irisin, especially in adipose tissue and metabolism.

ENDOCRINE REVIEWS (2021)

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Review Biochemistry & Molecular Biology

The role of Irisin in multiorgan protection

Jun Ma et al.

Summary: Physical exercise is effective for improving human health, with irisin as a muscle factor secreted after exercise that can protect multiple organs with different mechanisms. The role of irisin in multiorgan protection is gradually being revealed through research on its underlying molecular mechanisms.

MOLECULAR BIOLOGY REPORTS (2021)

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Review Biochemistry & Molecular Biology

Clinical and Molecular Biomarkers for Diagnosis and Staging of NAFLD

Stefania Di Mauro et al.

Summary: NAFLD, a common liver disease in industrialized countries, can progress to serious conditions. Liver biopsy is the gold standard for diagnosis, but non-invasive biomarkers are needed to identify high-risk patients.Various omics approaches are being explored to uncover novel biomarkers for accurate NAFL/NASH diagnosis and fibrosis staging.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, General & Internal

Prediction of Nonalcoholic Fatty Liver Disease Using Noninvasive and Non-Imaging Procedures in Japanese Health Checkup Examinees

Kenichiro Murayama et al.

Summary: This study evaluated the diagnostic performance of noninvasive and nonimaging indexes for predicting NAFLD in the general Japanese population, finding that all indexes were useful in diagnosing NAFLD in this population. The ZJU index and FLI showed significantly greater diagnostic performance compared to the HSI, especially in subjects with potentially advanced liver fibrosis.

DIAGNOSTICS (2021)

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Article Acoustics

Utility of quantitative ultrasound in community screening for hepatic steatosis

Tu-Yung Chang et al.

Summary: This study investigated the utility of quantitative ultrasound for screening hepatic steatosis and metabolic evaluation at the community level. The results showed that ultrasound ISE could be a potential imaging biomarker during first-line community screening for hepatic steatosis and insulin resistance.

ULTRASONICS (2021)

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Review Endocrinology & Metabolism

The Relationship Between Type 2 Diabetes, NAFLD, and Cardiovascular Risk

Cyrielle Caussy et al.

Summary: NAFLD and T2DM are strongly associated with an increased risk of cardiovascular disease. Patients with both conditions may have a synergistic increase in cardiovascular risk. Certain anti-diabetic therapies have shown beneficial effects on both NAFLD and CVD.

CURRENT DIABETES REPORTS (2021)

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Review Endocrinology & Metabolism

Association Between Serum Irisin and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis

Rui Wang et al.

Summary: A meta-analysis found that serum irisin levels may be associated with albuminuria and reduced glomerular filtration rate in patients with type 2 diabetes.

HORMONE AND METABOLIC RESEARCH (2021)

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Letter Endocrinology & Metabolism

Irisin in nonalcoholic fatty liver disease: Need for an updated meta-analysis

Stergios A. Polyzos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Review Medicine, General & Internal

The Troubling Link Between Non-alcoholic Fatty Liver Disease (NAFLD) and Extrahepatic Cancers (EHC)

Ajit Venniyoor et al.

Summary: NAFLD, a fast-spreading epidemic, is associated with increased risks of various cancers beyond liver cancer. Early recognition and intervention are crucial in altering its natural history and associated complications.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Article Medicine, General & Internal

Association of Hepatic Steatosis Index and Fatty Liver Index with Carotid Atherosclerosis in 2 Diabetes

Chenxi Wang et al.

Summary: The study found that HSI and FLI are independently correlated with carotid atherosclerosis in patients with type 2 diabetes mellitus. Increasing values of HSI and FLI were significantly associated with CIMT across different age and hypertension categories. These indices may serve as simple and useful markers for evaluating the progression of diabetic macrovascular complications.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2021)

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Article Nutrition & Dietetics

Aerobic exercise training-induced irisin secretion is associated with the reduction of arterial stiffness via nitric oxide production in adults with obesity

Kenichiro Inoue et al.

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM (2020)

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Article Biochemistry & Molecular Biology

Oxidative Stress and Pro-Inflammatory Status in Patients with Non-Alcoholic Fatty Liver Disease

Margalida Monserrat-Mesquida et al.

ANTIOXIDANTS (2020)

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Review Gastroenterology & Hepatology

Circulating Irisin Levels in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Jie Hu et al.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2020)

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Article Gastroenterology & Hepatology

Comparison of four non-alcoholic fatty liver disease detection scores in a Caucasian population

Lars Lind et al.

WORLD JOURNAL OF HEPATOLOGY (2020)

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Review Gastroenterology & Hepatology

Recent advances in non-invasive diagnosis and medical management of non-alcoholic fatty liver disease in adult

Jayanta Paul

EGYPTIAN LIVER JOURNAL (2020)

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Article Gastroenterology & Hepatology

A polymorphism in the Irisin-encoding gene (FNDC5) associates with hepatic steatosis by differential miRNA binding to the 3′UTR

Mayada Metwally et al.

JOURNAL OF HEPATOLOGY (2019)

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Review Sport Sciences

Effect of an acute exercise bout on immediate post-exercise irisin concentration in adults: A meta-analysis

J. Fox et al.

SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS (2018)

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Article Medicine, General & Internal

Non-alcoholic fatty liver disease

James Maurice et al.

CLINICAL MEDICINE (2018)

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Review Endocrinology & Metabolism

Irisin in metabolic diseases

Stergios A. Polyzos et al.

ENDOCRINE (2018)

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Review Gastroenterology & Hepatology

Non-alcoholic fatty liver disease and the interface between primary and secondary care

Emmanuel A. Tsochatzis et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2018)

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Review Physiology

Crosstalk between adipokines and myokines in fat browning

A. Rodriguez et al.

ACTA PHYSIOLOGICA (2017)

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Review Endocrinology & Metabolism

Physiology and role of irisin in glucose homeostasis

Nikolaos Perakakis et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

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Article Cell Biology

Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury

Ken Chen et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

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Article Multidisciplinary Sciences

Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys

Hui Peng et al.

NATURE COMMUNICATIONS (2017)

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Article Endocrinology & Metabolism

Lower circulating irisin is associated with nonalcoholic fatty liver disease and type 2 diabetes

Mehrnoosh Shanaki et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2017)

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Review Gastroenterology & Hepatology

Non-alcoholic Fatty Liver Disease: A Clinical Update

Joseph M. Pappachan et al.

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

Fatty liver index vs waist circumference for predicting non-alcoholic fatty liver disease

Nima Motamed et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

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Article Endocrinology & Metabolism

The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study

Anna Viitasalo et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2015)

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Article Endocrinology & Metabolism

Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice

A. Rodriguez et al.

INTERNATIONAL JOURNAL OF OBESITY (2015)

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Letter Endocrinology & Metabolism

Association between circulating irisin and homocysteine in patients with nonalcoholic fatty liver disease

Stergios A. Polyzos et al.

ENDOCRINE (2015)

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Article Endocrinology & Metabolism

Irisin in patients with nonalcoholic fatty liver disease

Stergios A. Polyzos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2014)

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Article Endocrinology & Metabolism

Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk

Grigorios Panagiotou et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2014)

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Article Multidisciplinary Sciences

Association between Serum Irisin Levels and Non-Alcoholic Fatty Liver Disease in Health Screen Examinees

Eun Sung Choi et al.

PLOS ONE (2014)

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Article Biochemistry & Molecular Biology

The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer IMPLICATIONS FOR RECEPTOR ACTIVATION

Maria A. Schumacher et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Article Multidisciplinary Sciences

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Pontus Bostroem et al.

NATURE (2012)

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Article Endocrinology & Metabolism

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

Joo Young Huh et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2012)

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Article Gastroenterology & Hepatology

Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease

Jeong-Hoon Lee et al.

DIGESTIVE AND LIVER DISEASE (2010)

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Irisin Is Related to Non-Alcoholic Fatty Liver Disease (NAFLD)

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