Journal
BIOMEDICINES
Volume 10, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines10112725
Keywords
finasteride; androgen imbalance; androgen receptor; endoplasmic reticulum stress; oxidative stress; liver; filial generation
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Funding
- Pomeranian Medical University [WMS-167-02/S/16/2022]
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Finasteride causes androgen imbalance, leading to ERet stress and liver disorders. UPR and ERAD are two pathways involved in cellular protein quality control in ERet. Paternal androgen imbalance may affect liver function in offspring through ERet stress, and oxidative stress is also a factor affecting ERet function.
Finasteride (Fin) causes androgen imbalance by inhibiting the conversion of testosterone (T) to its more active metabolite, dihydrotestosterone (DHT). Androgen receptors (AR) are present (e.g., in hepatocytes), which have well-developed endoplasmic reticulum (ERet). Cellular protein quality control is carried out by ERet in two paths: (i) unfolded protein response (UPR) and/or (ii) endoplasmic reticulum associated degradation (ERAD). ERet under continuous stress can generate changes in the UPR and can direct the cell on the pathway of life or death. It has been demonstrated that genes involved in ERet stress are among the genes controlled by androgens in some tissues. Oxidative stress is also one of the factors affecting the functions of ERet and androgens are one of the regulators of antioxidant enzyme activity. In this paper, we discuss/analyze a possible relationship between androgen imbalance in paternal generation with ERet stress and liver disorders in both paternal and filial generation. In our rat model, hyperglycemia and subsequent higher accumulation of hepatic glycogen were observed in all filial generation obtained from females fertilized by Fin-treated males (F1:Fin). Importantly, genes encoding enzymes involved in glucose and glycogen metabolism have been previously recognized among UPR targets.
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