Responsive Neurostimulation for Seizure Control: Current Status and Future Directions

Electrocorticography (ECoG) data are commonly obtained during drug-resistant epilepsy (DRE) workup, in which subdural grids and stereotaxic depth electrodes are placed on the cortex for weeks at a time, with the goal of elucidating seizure origination. ECoG data can also be recorded from neuromodulatory devices, such as responsive neurostimulation (RNS), which involves the placement of electrodes deep in the brain. Of the neuromodulatory devices, RNS is the first to use recorded ECoG data to direct the delivery of electrical stimulation in order to control seizures. In this review, we first introduced the clinical management for epilepsy, and discussed the steps from seizure onset to surgical intervention. We then reviewed studies discussing the emergence and therapeutic mechanism behind RNS, and discussed why RNS may be underperforming despite an improved seizure detection mechanism. We discussed the potential utility of incorporating machine learning techniques to improve seizure detection in RNS, and the necessity to change RNS targets for stimulation, in order to account for the network theory of epilepsy. We concluded by commenting on the current and future status of neuromodulation in managing epilepsy, and the role of predictive algorithms to improve outcomes.

Automated summary

This review introduces the clinical management of epilepsy and the steps involved in surgical intervention. It discusses the emergence and therapeutic mechanism of responsive neurostimulation (RNS), a neuromodulatory device that uses recorded ECoG data to control seizures. The review explores the underperformance of RNS despite improved seizure detection mechanisms, and suggests the potential utility of incorporating machine learning techniques and adjusting stimulation targets based on the network theory of epilepsy. The current and future status of neuromodulation in epilepsy management, as well as the role of predictive algorithms, are also discussed.