4.7 Article

Alteration of Mitochondrial DNA Copy Number and Increased Expression Levels of Mitochondrial Dynamics-Related Genes in Sjogren's Syndrome

Related references

Note: Only part of the references are listed.
Article Allergy

Antimitochondrial Antibodies: from Bench to Bedside

Francesca Colapietro et al.

Summary: Anti-mitochondrial antibodies (AMA) are typical biomarkers of primary biliary cholangitis (PBC) and are highly specific for diagnosis, although they can also be detected in healthy individuals. Managing patients without liver disease symptoms remains a challenge.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2022)

Article Immunology

A Link Between Mitochondrial Dysfunction and the Immune Microenvironment of Salivary Glands in Primary Sjogren's Syndrome

Ning Li et al.

Summary: This study revealed the interaction between mitochondrial dysfunction and the immune microenvironment in salivary glands of pSS patients and provided important insights into the clinical management of SS based on modulation of mitochondrial function.

FRONTIERS IN IMMUNOLOGY (2022)

Article Genetics & Heredity

Mitochondrial Displacement Loop Region SNPs Modify Sjogren's Syndrome Development by Regulating Cytokines Expression in Female Patients

Yufei Zhao et al.

Summary: Mitochondrial dysfunction could induce innate immune response with cytokines releasing to initiate Sjogren's syndrome (SS) onset. This study found that female SS patients had SNP associations in certain sites of the mitochondrial D-loop, and there was also an accumulation of SNPs in the D-loop region. Additionally, the mtDNA copy number increased in SS patients. Further analysis showed significant correlations between certain SNPs associated with SS risk and specific cytokine levels.

FRONTIERS IN GENETICS (2022)

Review Rheumatology

Genetics and epigenetics in primary Sjogren's syndrome

Juliana Imgenberg-Kreuz et al.

Summary: Primary Sjogren's syndrome (pSS) is a multifactorial disease with underlying genetic predisposition, epigenetic mechanisms and environmental factors playing roles in disease development. The strongest association signal lies within the HLA genes, with most genetic risk variants found at intergenic regions whose functional impact remains unclear. Epigenetic mechanisms like DNA methylation and histone modifications modulate gene expression, forming a dynamic link between the genome and phenotypic manifestations in pSS.

RHEUMATOLOGY (2021)

Article Biology

High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo

Nina A. Bonekamp et al.

Summary: TFAM plays a crucial role in maintaining normal mtDNA expression in different tissues, with its ratio to mtDNA being a key factor. It acts as a general repressor of mtDNA expression, but this effect can be counterbalanced by tissue-specific regulatory factors.

LIFE SCIENCE ALLIANCE (2021)

Article Cell Biology

Mff oligomerization is required for Drp1 activation and synergy with actin filaments during mitochondrial division

Ao Liu et al.

Summary: Mitochondrial division factor Mff is a dynamic oligomer that plays a key role in the activation of dynamin GTPase Drp1. Actin filaments enhance Mff-mediated Drp1 activation by lowering the effective Mff concentration 10-fold. Mff oligomerization is crucial for mitochondrial division and Drp1 recruitment in cells.

MOLECULAR BIOLOGY OF THE CELL (2021)

Review Immunology

Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjo¨gren's syndrome

Maria-Jose Barrera et al.

Summary: The dysfunction of mitochondria can disrupt cellular homeostasis and trigger inflammatory responses by releasing DAMPs, including cardiolipin, mtDNA, and formylated peptides. MERCs are crucial for maintaining calcium homeostasis and regulating inflammatory signaling, with alterations potentially contributing to autoimmune diseases. Understanding these mechanisms is essential for developing targeted therapies for inflammatory conditions.

AUTOIMMUNITY REVIEWS (2021)

Review Cell Biology

Mitochondria: the indispensable players in innate immunity and guardians of the inflammatory response

Abhishek Mohanty et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2019)

Review Biochemistry & Molecular Biology

The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms

Inhae Kang et al.

FEBS LETTERS (2018)

Article Medicine, General & Internal

Primary Sjogren's Syndrome

Xavier Mariette et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Biochemistry & Molecular Biology

Mitochondria as a centrally positioned hub in the innate immune response

Rajat Sandhir et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Article Cardiac & Cardiovascular Systems

Mitochondrial pathways to cardiac recovery: TFAM

George H. Kunkel et al.

HEART FAILURE REVIEWS (2016)

Article Biochemistry & Molecular Biology

Mitochondrial reactive oxygen species and inflammation: Molecular mechanisms, diseases and promising therapies

Alessandro Rimessi et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

Review Rheumatology

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

Ursula Fearon et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

Article Rheumatology

Autoantibodies in Sjogren's Syndrome

Anum Fayyaz et al.

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2016)

Article Medicine, General & Internal

Astrocytes Protect Neurons from Aβ1-42 Peptide-Induced Neurotoxicity Increasing TFAM and PGC-1 and Decreasing PPAR-γ and SIRT-1

Diana Aguirre-Rueda et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2015)

Review Biochemistry & Molecular Biology

Regulation and Physiologic Functions of GTPases in Mitochondrial Fusion and Fission in Mammals

Naotada Ishihara et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Genetics & Heredity

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

David C. Chan

ANNUAL REVIEW OF GENETICS, VOL 46 (2012)

Article Biochemistry & Molecular Biology

The intracellular redox state is a core determinant of mitochondrial fusion

Timothy Shutt et al.

EMBO REPORTS (2012)

Article Biochemistry & Molecular Biology

Oxidative stress, as measured by protein oxidation, is increased in primary Sjogren's syndrome

Katrine Braekke Norheim et al.

FREE RADICAL RESEARCH (2012)

Review Multidisciplinary Sciences

Mitochondrial Fission, Fusion, and Stress

Richard J. Youle et al.

SCIENCE (2012)

Review Biochemistry & Molecular Biology

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

William I. Sivitz et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

Review Cell Biology

Mitochondrial fusion proteins: Dual regulators of morphology and metabolism

Antonio Zorzano et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Overexpression of Tfam protects mitochondria against β-amyloid-induced oxidative damage in SH-SY5Y cells

Shangcheng Xu et al.

FEBS JOURNAL (2009)

Review Biochemistry & Molecular Biology

Mitochondria in multiple sclerosis

Pedram Ghafourifar et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2008)

Article Oncology

Mitochondrial DNA content: Its genetic heritability and association with renal cell carcinoma

Jinliang Xing et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2008)

Review Clinical Neurology

Oxidative stress biology and cell injury during type 1 and type 2 diabetes Mellitus

Kenneth Maiese et al.

CURRENT NEUROVASCULAR RESEARCH (2007)

Article Biochemistry & Molecular Biology

TFAM-dependent and independent dynamics of mtDNA levels in C2C12 myoblasts caused by redox stress

H Noack et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2006)

Article Biochemistry & Molecular Biology

Mitochondrial transcription factor A regulates mtDNA copy number in mammals

MI Ekstrand et al.

HUMAN MOLECULAR GENETICS (2004)