Journal
BIOMEDICINES
Volume 10, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines10082018
Keywords
chemerin; proteases; obesity; diabetes
Categories
Funding
- Department of Veterans Affairs [I01BX001959]
- National Institutes of Health [HL057530]
Ask authors/readers for more resources
Chemerin, produced by the RARRES2 gene, undergoes activation and inactivation processes to exert its biological activity. It signals through various receptors and is expressed in multiple tissues. Methods for identifying different forms of Chemerin provide a means to study its biological function, and its levels in circulation may serve as a biomarker.
Chemerin is the product of the RARRES2 gene which is secreted as a precursor of 143 amino acids. That precursor is inactive, but proteases from the coagulation and fibrinolytic cascades, as well as from inflammatory reactions, process the C-terminus of chemerin to first activate it and then subsequently inactivate it. Chemerin can signal via two G protein-coupled receptors, chem1 and chem2, as well as be bound to a third non-signaling receptor, CCRL2. Chemerin is produced by the liver and secreted into the circulation as a precursor, but it is also expressed in some tissues where it can be activated locally. This review discusses the specific tissue expression of the components of the chemerin system, and the role of different proteases in regulating the activation and inactivation of chemerin. Methods of identifying and determining the levels of different chemerin forms in both mass and activity assays are reviewed. The levels of chemerin in circulation are correlated with certain disease conditions, such as patients with obesity or diabetes, leading to the possibility of using chemerin as a biomarker.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available