Related references
Note: Only part of the references are listed.Supersaturation-Dependent Formation of Amyloid Fibrils
Yuji Goto et al.
MOLECULES (2022)
Effect of Cholesterol on C99 Dimerization: Revealed by Molecular Dynamics Simulations
Cheng-Dong Li et al.
FRONTIERS IN MOLECULAR BIOSCIENCES (2022)
Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization
Vanessa F. Langness et al.
MOLECULAR BIOLOGY OF THE CELL (2021)
Mechanism of Cellular Formation and In Vivo Seeding Effects of Hexameric β-Amyloid Assemblies
Celine Vrancx et al.
MOLECULAR NEUROBIOLOGY (2021)
Highly accurate protein structure prediction with AlphaFold
John Jumper et al.
NATURE (2021)
An evaluation of the self-assembly enhancing properties of cell-derived hexameric amyloid-β
Devkee M. Vadukul et al.
SCIENTIFIC REPORTS (2021)
N-Terminally Truncated and Pyroglutamate-Modified Aβ Forms Are Measurable in Human Cerebrospinal Fluid and Are Potential Markers of Disease Progression in Alzheimer's Disease
Guido Domingo et al.
FRONTIERS IN NEUROSCIENCE (2021)
Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals
Benedikt Gille et al.
FRONTIERS IN AGING (2021)
Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides
Lei Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2021)
Complete aggregation pathway of amyloid beta (1-40) and (1-42) resolved on an atomically clean interface
Peter Niraj Nirmalraj et al.
SCIENCE ADVANCES (2020)
Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in Astrocytes
Ching-On Wong
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Cholesterol and Alzheimer's Disease Risk: A Meta-Meta-Analysis
Olalla Saiz-Vazquez et al.
BRAIN SCIENCES (2020)
Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization
Florian Perrin et al.
ISCIENCE (2020)
Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue
Marius Kollmer et al.
NATURE COMMUNICATIONS (2019)
The crystal structure of amyloid precursor-like protein 2 E2 domain completes the amyloid precursor protein family
Laila C. Roisman et al.
FASEB JOURNAL (2019)
Recognition of the amyloid precursor protein by human γ-secretase
Rui Zhou et al.
SCIENCE (2019)
Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA
Simone Eggert et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2018)
Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ - secretase cleavage sites
Yan Yan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Dimerization and Structural Stability of Amyloid Precursor Proteins Affected by the Membrane Microenvironments
Fude Sun et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization
Hidekazu Higashide et al.
JOURNAL OF NEUROCHEMISTRY (2017)
BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis
Shuting Zhang et al.
JOURNAL OF NEUROSCIENCE (2017)
Fibril structure of amyloid-β(1-42) by cryo-electron microscopy
Lothar Gremer et al.
SCIENCE (2017)
APP Function and Lipids: A Bidirectional Link
Marcus O. W. Grimm et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)
Amyloid β Modification: A Key to the Sporadic Alzheimer's Disease?
Evgeny P. Barykin et al.
FRONTIERS IN GENETICS (2017)
Role of the N-terminus for the stability of an amyloid-β fibril with three-fold symmetry
Christian A. Soeldner et al.
PLOS ONE (2017)
β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing
Yi Hu et al.
SCIENTIFIC REPORTS (2017)
Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity
Andreas Mueller-Schiffmann et al.
BRAIN (2016)
Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity
Sathish Kumar et al.
ACTA NEUROPATHOLOGICA (2016)
Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool
Ragna Sannerud et al.
CELL (2016)
Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence
Ayano Kimura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Impact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein
Laura Dominguez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway
Pinaki Misra et al.
NATURE COMMUNICATIONS (2016)
Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells
Marie Decock et al.
FRONTIERS IN AGING NEUROSCIENCE (2016)
The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
David M. Bolduc et al.
ELIFE (2016)
Mutants of Metal Binding Site M1 in APP E2 Show Metal Specific Differences in Binding of Heparin but Not of sorLA
Christian Dienemann et al.
BIOCHEMISTRY (2015)
Role of GxxxG Motifs in Transmembrane Domain Interactions
Mark G. Teese et al.
BIOCHEMISTRY (2015)
Presenilin Transmembrane Domain 8 Conserved AXXXAXXXG Motifs Are Required for the Activity of the gamma-Secretase Complex
Claudia Marinangeli et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
The case for rejecting the amyloid cascade hypothesis
Karl Herrup
NATURE NEUROSCIENCE (2015)
Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing
Marie Decock et al.
FEBS OPEN BIO (2015)
Novel Zinc-binding Site in the E2 Domain Regulates Amyloid Precursor-like Protein 1 (APLP1) Oligomerization
Magnus C. Mayer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain
Sandra Hoefgen et al.
JOURNAL OF STRUCTURAL BIOLOGY (2014)
Proteostasis and the Aging Proteome in Health and Disease
Richard I. Morimoto et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)
Cholesterol as a co-solvent and a ligand for membrane proteins
Yuanli Song et al.
PROTEIN SCIENCE (2014)
Conformational Changes Induced by the A21G Flemish Mutation in the Amyloid Precursor Protein Lead to Increased Aβ Production
Tzu-Chun Tang et al.
STRUCTURE (2014)
Truncated and modified amyloid-beta species
Markus P. Kummer et al.
ALZHEIMERS RESEARCH & THERAPY (2014)
Snapin-Mediated BACE1 Retrograde Transport Is Essential for Its Degradation in Lysosomes and Regulation of APP Processing in Neurons
Xuan Ye et al.
CELL REPORTS (2014)
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients
Adina N. Lazar et al.
ACTA NEUROPATHOLOGICA (2013)
Competition Between Homodimerization and Cholesterol Binding to the C99 Domain of the Amyloid Precursor Protein
Yuanli Song et al.
BIOCHEMISTRY (2013)
Self-interaction of transmembrane helices representing pre-clusters from the human single-span membrane proteins
Jan Kirrbach et al.
BIOINFORMATICS (2013)
Molecular Structure of β-Amyloid Fibrils in Alzheimer's Disease Brain Tissue
Jun-Xia Lu et al.
CELL (2013)
Amyloid- protein (A) Glu11 is the major -secretase site of -site amyloid- precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to A Asp1 contributes to Alzheimer pathogenesis
Yu Deng et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2013)
Redundancy and divergence in the amyloid precursor protein family
S. Ali M. Shariati et al.
FEBS LETTERS (2013)
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Chia-Chan Liu et al.
NATURE REVIEWS NEUROLOGY (2013)
Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway
Utpal Das et al.
NEURON (2013)
Copper enhances APP dimerization and promotes Aβ production
Yasuha Noda et al.
NEUROSCIENCE LETTERS (2013)
Biological function of Presenilin and its role in AD pathogenesis
Shuting Zhang et al.
TRANSLATIONAL NEURODEGENERATION (2013)
Nuclear signalling by membrane protein intracellular domains: The AICD enigma
Caroline Beckett et al.
CELLULAR SIGNALLING (2012)
Structural features of the KPI domain control APP dimerization, trafficking, and processing
Naouel Ben Khalifa et al.
FASEB JOURNAL (2012)
Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environment
Kirill D. Nadezhdin et al.
FEBS LETTERS (2012)
Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain
Sven O. Dahms et al.
JOURNAL OF MOLECULAR BIOLOGY (2012)
The physiology of the beta-amyloid precursor protein intracellular domain AICD
Raphaelle Pardossi-Piquard et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice
Tomohiro Umeda et al.
LIFE SCIENCES (2012)
The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol
Paul J. Barrett et al.
SCIENCE (2012)
Physiological Functions of APP Family Proteins
Ulrike C. Mueller et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
The Genetics of Alzheimer Disease
Rudolph E. Tanzi
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
The membrane-bound aspartyl protease BACE1: molecular and functional properties in Alzheimer's disease and beyond
Bastian Dislich et al.
FRONTIERS IN PHYSIOLOGY (2012)
The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization
Sangwon Lee et al.
BIOCHEMISTRY (2011)
Synergistic Interactions between Repeats in Tau Protein and Aβ Amyloids May Be Responsible for Accelerated Aggregation via Polymorphic States
Yifat Miller et al.
BIOCHEMISTRY (2011)
Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease
Sathish Kumar et al.
EMBO JOURNAL (2011)
Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein
Sarah A. Sagi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and γ-Secretase
Sebastian Hogl et al.
PLOS ONE (2011)
Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships?
Andrew J. Beel et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2010)
Lipids in Alzheimer's disease: A century-old story
Paul Foley
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2010)
ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons
Peer-Hendrik Kuhn et al.
EMBO JOURNAL (2010)
Aberrant Amyloid Precursor Protein (APP) Processing in Hereditary Forms of Alzheimer Disease Caused by APP Familial Alzheimer Disease Mutations Can Be Rescued by Mutations in the APP GxxxG Motif
Lisa-Marie Munter et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Insulin-like Growth Factor-1 (IGF-1)-induced Processing of Amyloid-β Precursor Protein (APP) and APP-like Protein 2 Is Mediated by Different Metalloproteinases
Kristin T. Jacobsen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Conservation of a Glycine-rich Region in the Prion Protein Is Required for Uptake of Prion Infectivity
Christopher F. Harrison et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
As Based upon Physiological and Pathological Histology
RUDOLF VIRCHOW
NUTRITION REVIEWS (2010)
Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein
Sven O. Dahms et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Amyloid beta 42 peptide (Aβ42)-lowering compounds directly bind to Aβ and interfere with amyloid precursor protein (APP) transmembrane dimerization
Luise Richter et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Induced Dimerization of the Amyloid Precursor Protein Leads to Decreased Amyloid-β Protein Production
Simone Eggert et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
γ-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of β-Carboxyl Terminal Fragment
Mako Takami et al.
JOURNAL OF NEUROSCIENCE (2009)
Transmembrane Structures of Amyloid Precursor Protein Dimer Predicted by Replica-Exchange Molecular Dynamics Simulations
Naoyuki Miyashita et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
A helix-to-coil transition at the ε-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis
Takeshi Sato et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): Does APP function as a cholesterol sensor?
Andrew J. Beel et al.
BIOCHEMISTRY (2008)
Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants
Paul M. Gorman et al.
BMC NEUROSCIENCE (2008)
Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs
Pascal Kienlen-Campard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42
Lisa-Marie Munter et al.
EMBO JOURNAL (2007)
Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
Ganesh M. Shankar et al.
JOURNAL OF NEUROSCIENCE (2007)
Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide
Christian Haass et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Loss-of-function presenilin mutations in Alzheimer disease - Talking Point on the role of presenilin mutations in Alzheimer disease
Bart De Strooper
EMBO REPORTS (2007)
High cholesterol content in neurons increases BACE, β-amyloid, and phosphorylated tau levels in rabbit hippocampus
Othman Ghribi et al.
EXPERIMENTAL NEUROLOGY (2006)
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes
Sebastien S. Hebert et al.
EMBO REPORTS (2006)
Inhibitors of amyloid toxicity based on β-sheet packing of Aβ40 and Aβ42
T Sato et al.
BIOCHEMISTRY (2006)
Effects of secreted oligomers of amyloid β-protein on hippocampal synaptic plasticity:: a potent role for trimers
M Townsend et al.
JOURNAL OF PHYSIOLOGY-LONDON (2006)
Presenilin clinical mutations can affect γ-secretase activity by different mechanisms
M Bentahir et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Homo- and heterodimerization of APP family members promotes intercellular adhesion
P Soba et al.
EMBO JOURNAL (2005)
The genetic epidemidogy of neurodegenerative disease
L Bertram et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves α-, β-, γ-, and ε-like cleavages -: Modulation of APLP-1 processing by N-glycosylation
S Eggert et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
A conserved GXXXG motif in APH-1 is critical for assembly and activity of the γ-secretase complex
SF Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Residues 17-20 and 30-35 of beta-amyloid play critical roles in aggregation
RT Liu et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2004)
The X-ray structure of an antiparaliel dimer of the human amyloid precursor protein E2 domain
YC Wang et al.
MOLECULAR CELL (2004)
Protein aggregation and neurodegenerative disease
CA Ross et al.
NATURE MEDICINE (2004)
Dissection of amyloid-β precursor protein-dependent transcriptional transactivation
XW Cao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein
JM Cordy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Reconstitution of γ-secretase activity
D Edbauer et al.
NATURE CELL BIOLOGY (2003)
Processing of β-amyloid precursor-like protein-1 and-2 by γ-secretase regulates transcription
MH Scheinfeld et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
DR Thal et al.
NEUROLOGY (2002)
A novel ε-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with notch processing
A Weidemann et al.
BIOCHEMISTRY (2002)
The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total Aβ
L Pastorino et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2002)
Distinct expression patterns of two zebrafish homologues of the human APP gene during embryonic development
A Musa et al.
DEVELOPMENT GENES AND EVOLUTION (2001)
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease
S Scheuermann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60
XW Cao et al.
SCIENCE (2001)
Midlife vascular risk factors and Alzheimer's disease in later life:: longitudinal, population based study
M Kivipelto et al.
BMJ-BRITISH MEDICAL JOURNAL (2001)
Maturation and endosomal targeting of β-site amyloid precursor protein-cleaving enzyme -: The Alzheimer's disease β-secretase
JT Huse et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The GxxxG motif: A framework for transmembrane helix-helix association
WP Russ et al.
JOURNAL OF MOLECULAR BIOLOGY (2000)