Journal
BIOMEDICINES
Volume 10, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines10112672
Keywords
lipid annulus; annular lipid; boundary lipid; intrinsic membrane proteins; lipid-protein interactions; resonance spectroscopies
Categories
Funding
- Spanish Ministerio de Ciencia e Innovacion (MCI)
- Agencia Estatal de Investigacion (AEI)
- Fondo Europeo de Desarrollo Regional (FEDER) [PID2021-124461NB-I00]
- Basque Government [IT1625-22]
- Fundacion Ramon Areces [CIVP20A6619]
- Fundacion Biofisica Bizkaia
- Basque Excellence Research Centre (BERC) program of the Basque Government
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In the early 1970s, the idea of a lipid annulus surrounding intrinsic protein molecules was proposed but later proven incorrect.
In the early 1970s, the existence of a lipid annulus stably surrounding the individual intrinsic protein molecules was proposed by several authors. They referred to a number of lipid molecules in slow exchange with the bulk lipid in the bilayer, i.e., more or less protein-bound, and more ordered than the bulk lipid. The annular lipids would control enzyme activity. This idea was uncritically accepted by most scientists working with intrinsic membrane proteins at the time, so that the idea operated like a myth in the field. However, in the following decade, hard spectroscopic and biochemical evidence showed that the proposed annular lipids were not immobilized for a sufficiently long time to influence enzyme or transporter activity, nor were they ordered by the protein. Surprisingly, forty years later, the myth survives, and the term 'annular lipid' is still in use, in a different, but even more illogical sense.
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