Journal
BIOMEDICINES
Volume 10, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines10102451
Keywords
endometriosis; ELISA; infertility; PARP; peritoneal fluid; plasma
Categories
Funding
- Polish Ministry of Health [6/6/4/1/NPZ/2017/1210/13522]
- Medical University of Warsaw, Poland [1W51/1/M/MB/N/20]
- European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant [101008193 TRENDO]
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This study evaluated the levels of PARP in plasma and peritoneal fluid of patients with and without endometriosis. The results showed no significant differences in PARP concentrations between patients with and without endometriosis. However, a higher plasma PARP concentration was associated with a history of infertility.
The evidence of poly (ADP-ribose) polymerase (PARP) association with the immune response could be coherent with the immunological theory of endometriosis and suggests the possibility of a new research direction. The aim of the study was to evaluate the levels of PARP in plasma and peritoneal fluid of patients with and without endometriosis. It was a multicenter, cross-sectional study. Plasma and peritoneal fluid samples were collected from patients with and without endometriosis during planned laparoscopic procedures in eight clinical centers. In total, 84 samples of plasma and 84 samples of the peritoneal fluid were included in the final analyses. Double-antibody sandwich enzyme-linked immunosorbent assay was performed in order to assess levels of PARP in collected samples. No statistically significant differences regarding the detected levels of PARP in plasma and peritoneal fluid comparing patients with and without endometriosis were observed. Patients with a history of infertility had significantly higher plasma PARP concentrations (p = 0.04). We have not observed the potential role of PARP concentration levels in plasma nor peritoneal fluid as an endometriosis biomarker. We have determined an association between a higher plasma PARP concentration and a history of infertility.
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