Journal
BIOMEDICINES
Volume 10, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines10102399
Keywords
outer membrane vesicles; antimicrobial activity; Gram-negative bacteria; Gram-positive bacteria
Categories
Funding
- FCT-Fundacao para a Ciencia e a Tecnologia [UIDB/04539/2020, UIDP/04539/2020, LA/P/0058/2020]
- Fundacao para a Ciencia e a Tecnologia (FCT) [SFRH/BD/06289/2021]
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Outer membrane vesicles (OMV) released from Gram-negative bacteria can carry molecules with antibacterial activity, making them potential tools for delivering antimicrobial agents.
Gram-negative bacteria are intrinsically resistant to many commercialized antibiotics. The outer membrane (OM) of Gram-negative bacteria prevents the entry of such antibiotics. Outer membrane vesicles (OMV) are naturally released from the OM of Gram-negative bacteria for a range of purposes, including competition with other bacteria. OMV may carry, as part of the membrane or lumen, molecules with antibacterial activity. Such OMV can be exposed to and can fuse with the cell surface of different bacterial species. In this review we consider how OMV can be used as tools to deliver antimicrobial agents. This includes the characteristics of OMV production and how this process can be used to create the desired antibacterial activity of OMV.
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