4.7 Article

Unexpected Heterogeneity of Newly Diagnosed Multiple Myeloma Patients with Plasmacytomas

Related references

Note: Only part of the references are listed.
Article Hematology

Identification of patients at high risk of secondary extramedullary multiple myeloma development

Martin Stork et al.

Summary: The study identified younger age, high lactate dehydrogenase levels, extensive osteolytic activity, immunoglobulin A or the non-secretory type of MM as main risk factors for secondary EMD development in MM patients. Additionally, MM patients with specific risk factors associated with secondary EMD development were found to have a more aggressive disease course before the development of secondary EMD.

BRITISH JOURNAL OF HAEMATOLOGY (2022)

Article Hematology

Prognostic value of minimal residual disease negativity in myeloma: combined analysis of POLLUX, CASTOR, ALCYONE, and MAIA

Michele Cavo et al.

Summary: In this study, we explored the impact of minimal residual disease (MRD) on relapsed/refractory multiple myeloma (RRMM) and transplant-ineligible newly diagnosed multiple myeloma (TIE NDMM). The results showed that achieving complete response or better (>= CR) and MRD negativity were associated with improved progression-free survival (PFS) in both RRMM and TIE NDMM patients, regardless of the type of therapy or disease setting.

BLOOD (2022)

Review Oncology

Extramedullary disease in multiple myeloma: a systematic literature review

Joan Blade et al.

Summary: Extramedullary involvement is an aggressive form of multiple myeloma, with varied typical sites and incidence rates. Patients with EMD have poor prognosis and lower treatment efficacy. The lack of prospective studies limits strong recommendations for treatment approaches.

BLOOD CANCER JOURNAL (2022)

Article Oncology

Proteomic analysis of the bone marrow microenvironment in extramedullary multiple myeloma patients

Jana Gregorova et al.

Summary: This study identified different expression levels of cytokines in the bone marrow (BM) plasma of multiple myeloma (MM) and extramedullary disease (EMD) patients. These cytokines were found to be significantly associated with clinicopathological features of MM/EMD patients and play important roles in various signaling pathways and cellular processes. The results confirm the crucial role of the BM microenvironment in MM pathogenesis and highlight the importance of cytokines in disease progression and EMD development.

NEOPLASMA (2022)

Article Oncology

Standardization of 18F-FDG-PET/CT According to Deauville Criteria for Metabolic Complete Response Definition in Newly Diagnosed Multiple Myeloma

Elena Zamagni et al.

Summary: This study analyzed the metabolic response of PET/CT scans in newly diagnosed transplantation-eligible patients with multiple myeloma, and found that FL and bone marrow FDG uptake lower than liver background could predict prolonged progression-free survival and overall survival, suggesting their value as standardized criteria for PET complete metabolic response in patients with MM.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Review Hematology

Expert review on soft-tissue plasmacytomas in multiple myeloma: definition, disease assessment and treatment considerations

Laura Rosinol et al.

Summary: This review identifies two types of soft-tissue involvement in multiple myeloma: EMD and PS. EMD disease is associated with high-risk cytogenetics, therapy resistance, and worse prognosis. For patients with PS involvement, a proteasome inhibitor-based regimen may be the best option.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

Review Oncology

Roadmap to cure multiple myeloma

Paula Rodriguez-Otero et al.

Summary: In order to achieve a cure for multiple myeloma, five complementary strategies are proposed: increasing knowledge about disease pathogenesis, using undetectable measurable residual disease as the new endpoint of therapy, treating disease causation instead of symptomatology, using the most active scheme, and investigating experimental therapies.

CANCER TREATMENT REVIEWS (2021)

Article Oncology

Multiple Extramedullary-Bone Related and/or Extramedullary Extraosseous Are Independent Poor Prognostic Factors in Patients With Newly Diagnosed Multiple Myeloma

JingSong He et al.

Summary: This study found that multiple sites of EMB and/or EME are independent poor prognostic factors for newly diagnosed MM patients treated with bortezomib-based regimens, while a single site of EMB does not affect patients' survival. Multiple sites of EMB and/or EME are prognostic predictors affecting PFS and OS in newly diagnosed MM patients.

FRONTIERS IN ONCOLOGY (2021)

Review Oncology

Extramedullary disease in multiple myeloma

Radhika Bansal et al.

Summary: Extramedullary multiple myeloma (EMD) is a challenging disease from therapeutic and biological perspectives, with unclear pathogenetic mechanisms. In the era of novel agents, there is a rising incidence of EMD, but lack of standard treatment approaches.

BLOOD CANCER JOURNAL (2021)

Article Medicine, General & Internal

Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma

T. Facon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Editorial Material Oncology

HAEMATOLOGICAL CANCER Where are we now with the treatment of multiple myeloma?

Gareth J. Morgan et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Article Medicine, General & Internal

Multiple myeloma

Shaji K. Kumar et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Article Hematology

Cytogenetics in multiple myeloma patients progressing into extramedullary disease

Lenka Besse et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2016)

Article Biotechnology & Applied Microbiology

Extramedullary Manifestation in Multiple Myeloma Bears High Incidence of Poor Cytogenetic Aberration and Novel Agents Resistance

Xiaoyan Qu et al.

BIOMED RESEARCH INTERNATIONAL (2015)