Modulating neuroinflammation through molecular, cellular and biomaterial-based approaches to treat spinal cord injury

The neuroinflammatory response that is elicited after spinal cord injury contributes to both tissue damage and reparative processes. The complex and dynamic cellular and molecular changes within the spinal cord microenvironment result in a functional imbalance of immune cells and their modulatory factors. To facilitate wound healing and repair, it is necessary to manipulate the immunological pathways during neuroinflammation to achieve successful therapeutic interventions. In this review, recent advancements and fresh perspectives on the consequences of neuroinflammation after SCI and modulation of the inflammatory responses through the use of molecular-, cellular-, and biomaterial-based therapies to promote tissue regeneration and functional recovery will be discussed.

Automated summary

The neuroinflammatory response after spinal cord injury plays a role in both tissue damage and repair. Manipulating the immune pathways is necessary for successful therapeutic interventions. This review discusses recent advancements and fresh perspectives on using molecular, cellular, and biomaterial-based therapies to modulate inflammatory responses and promote tissue regeneration and functional recovery.