Related references
Note: Only part of the references are listed.Targeting α-synuclein aggregation and its role in mitochondrial dysfunction in Parkinson's disease
Md Ezazul Haque et al.
BRITISH JOURNAL OF PHARMACOLOGY (2022)
ERRγ ligand HPB2 upregulates BDNF-TrkB and enhances dopaminergic neuronal phenotype
Hyo In Kim et al.
PHARMACOLOGICAL RESEARCH (2021)
Disruption of mitochondrial complex I induces progressive parkinsonism
Patricia Gonzalez-Rodriguez et al.
NATURE (2021)
Estrogen-related Receptor Alpha (ERRα) is Required for PGC-1α-dependent Gene Expression in the Mouse Brain
L. J. McMeekin et al.
NEUROSCIENCE (2021)
Hippocampal network hyperexcitability in young transgenic mice expressing human mutant alpha-synuclein
Clare Tweedy et al.
NEUROBIOLOGY OF DISEASE (2021)
Molecular Mechanisms Underlying Synaptic and Axon Degeneration in Parkinson's Disease
Nolwazi Z. Gcwensa et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2021)
Dysregulation of PGC-1α-Dependent Transcriptional Programs in Neurological and Developmental Disorders: Therapeutic Challenges and Opportunities
Laura J. McMeekin et al.
CELLS (2021)
Function and Regulation of ALDH1A1-Positive Nigrostriatal Dopaminergic Neurons in Motor Control and Parkinson's Disease
Kathleen Carmichael et al.
FRONTIERS IN NEURAL CIRCUITS (2021)
Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality
Jaime Lasheras et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Estrogen-related receptors are targetable ROS sensors
Mathieu Vernier et al.
GENES & DEVELOPMENT (2020)
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
Anne-Laure Mahul-Mellier et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation
Tomoya Sakamoto et al.
CIRCULATION RESEARCH (2020)
A Role for PGC-1α in Transcription and Excitability of Neocortical and Hippocampal Excitatory Neurons
L. J. McMeekin et al.
NEUROSCIENCE (2020)
Regulation of dopaminergic neuronal phenotypes by the estrogen-related receptor gamma ligand GSK4716 via the activation of CREB signaling
Juhee Lim et al.
NEUROCHEMISTRY INTERNATIONAL (2020)
Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization
Stephanie Shiers et al.
PAIN (2020)
Overexpression of PGC-1α influences the mitochondrial unfolded protein response (mtUPR) induced by MPP+ in human SH-SY5Y neuroblastoma cells
Yousheng Cai et al.
SCIENTIFIC REPORTS (2020)
Orphan Nuclear Receptor ERRγ Is a Novel Transcriptional Regulator of IL-6 Mediated Hepatic BMP6 Gene Expression in Mice
Kamalakannan Radhakrishnan et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Clinical trials in mitochondrial disorders, an update
Mohammed Almannai et al.
MOLECULAR GENETICS AND METABOLISM (2020)
Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons
Rebekah C. Evans et al.
CELL REPORTS (2020)
Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein
Raquel Pinho et al.
HUMAN MOLECULAR GENETICS (2019)
Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration
Xinhe Wang et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)
Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice
Jessica M. Froula et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons
Qihui Wu et al.
JOURNAL OF NEUROSCIENCE (2019)
Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning
Junbing Wu et al.
CELL REPORTS (2019)
Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils
Joseph R. Patterson et al.
NEUROBIOLOGY OF DISEASE (2019)
The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration
Danielle E. Mor et al.
MOVEMENT DISORDERS (2019)
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Mike A. Nalls et al.
LANCET NEUROLOGY (2019)
PGC-1 alpha sparks the fire of neuroprotection against neurodegenerative disorders
Jianjun Lv et al.
AGEING RESEARCH REVIEWS (2018)
Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists
Hua Lin et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)
Cell-Specific Deletion of PGC-1 alpha from Medium Spiny Neurons Causes Transcriptional Alterations and Age-Related Motor Impairment
Laura J. McMeekin et al.
JOURNAL OF NEUROSCIENCE (2018)
Detecting Alpha Synuclein Seeding Activity in Formaldehyde-Fixed MSA Patient Tissue by PMCA
Katelyn Becker et al.
MOLECULAR NEUROBIOLOGY (2018)
Current perspective of mitochondrial biology in Parkinson's disease
Navneet Ammal Kaidery et al.
NEUROCHEMISTRY INTERNATIONAL (2018)
Characterization of Dopaminergic System in the Striatum of Young Adult Park2-/- Knockout Rats
Jickssa M. Gemechu et al.
SCIENTIFIC REPORTS (2018)
Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain
Arpiar Saunders et al.
CELL (2018)
Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function
Isabel Paiva et al.
NEUROBIOLOGY OF DISEASE (2018)
Neonatal 6-OHDA lesion model in mouse induces Attention-Deficit/Hyperactivity Disorder (ADHD)-like behaviour
Otmane Bouchatta et al.
SCIENTIFIC REPORTS (2018)
Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage
Isabel Paiva et al.
HUMAN MOLECULAR GENETICS (2017)
Therapies for mitochondrial diseases and current clinical trials
Ayman W. El-Hattab et al.
MOLECULAR GENETICS AND METABOLISM (2017)
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
Diana Chang et al.
NATURE GENETICS (2017)
Selective neuronal vulnerability in Parkinson disease
D. James Surmeier et al.
NATURE REVIEWS NEUROSCIENCE (2017)
ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues
Hanna Bayer et al.
NEUROBIOLOGY OF DISEASE (2017)
ERRγ: a Junior Orphan with a Senior Role in Metabolism
Jagannath Misra et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)
Roundabout receptor 2 maintains inhibitory control of the adult midbrain
Bryan B. Gore et al.
ELIFE (2017)
Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments
Panchanan Maiti et al.
TRANSLATIONAL NEURODEGENERATION (2017)
Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production
Victor Tapias et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
Overexpression of PGC-1α Influences Mitochondrial Signal Transduction of Dopaminergic Neurons
Qinyong Ye et al.
MOLECULAR NEUROBIOLOGY (2016)
Cortical PGC-1α-Dependent Transcripts Are Reduced in Postmortem Tissue From Patients With Schizophrenia
Laura J. McMeekin et al.
SCHIZOPHRENIA BULLETIN (2016)
Is age-related failure of metabolic reprogramming a principal mediator in idiopathic Parkinson's disease? Implications for treatment and inverse cancer risk
Peter A. Engel
MEDICAL HYPOTHESES (2016)
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
Maxim V. Kuleshov et al.
NUCLEIC ACIDS RESEARCH (2016)
Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons
Haisong Jiang et al.
ENEURO (2016)
Constitutive activities of estrogen-related receptors: Transcriptional regulation of metabolism by the ERR pathways in health and disease
Janice M. Huss et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)
Dependence of Hippocampal Function on ERRγ-Regulated Mitochondrial Metabolism
Liming Pei et al.
CELL METABOLISM (2015)
Estrogen-Related Receptor α (ERRα) and ERRγ Are Essential Coordinators of Cardiac Metabolism and Function
Ting Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2015)
The ImageJ ecosystem: An open platform for biomedical image analysis
Johannes Schindelin et al.
MOLECULAR REPRODUCTION AND DEVELOPMENT (2015)
Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
Katrina L. Paumier et al.
NEUROBIOLOGY OF DISEASE (2015)
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson's Disease
Alicia M. Pickrell et al.
NEURON (2015)
PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein
Carine Ciron et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
HTSeq-a Python framework to work with high-throughput sequencing data
Simon Anders et al.
BIOINFORMATICS (2015)
PINK1 Heterozygous Mutations Induce Subtle Alterations in Dopamine-Dependent Synaptic Plasticity
Graziella Madeo et al.
MOVEMENT DISORDERS (2014)
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
Mike A. Nalls et al.
NATURE GENETICS (2014)
Cell type-specific mRNA purification by translating ribosome affinity purification (TRAP)
Myriam Heiman et al.
NATURE PROTOCOLS (2014)
ULTRASTRUCTURAL LOCALIZATION OF TYROSINE HYDROXYLASE IN TREE SHREW NUCLEUS ACCUMBENS CORE AND SHELL
L. A. McCollum et al.
NEUROSCIENCE (2014)
Molecular determinants of selective dopaminergic vulnerability in Parkinson's disease: an update
Lars Brichta et al.
FRONTIERS IN NEUROANATOMY (2014)
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Michael I. Love et al.
GENOME BIOLOGY (2014)
STAR: ultrafast universal RNA-seq aligner
Alexander Dobin et al.
BIOINFORMATICS (2013)
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
Edward Y. Chen et al.
BMC BIOINFORMATICS (2013)
Impaired myogenesis in estrogen-related receptor γ (ERRγ)-deficient skeletal myocytes due to oxidative stress
Jennifer Murray et al.
FASEB JOURNAL (2013)
Parkinson's Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress
Sarah Ciccone et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)
Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism
Zhenji Gan et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Large-scale gene function analysis with the PANTHER classification system
Huaiyu Mi et al.
NATURE PROTOCOLS (2013)
α-Synuclein and Mitochondria: Partners in Crime?
Ken Nakamura
NEUROTHERAPEUTICS (2013)
The Asymmetric Binding of PGC-1α to the ERRα and ERRγ Nuclear Receptor Homodimers Involves a Similar Recognition Mechanism
Maria Takacs et al.
PLOS ONE (2013)
Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification
Pingzhu Zhou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Mitochondrial dysfunction and oxidative stress in Parkinson's disease
Sudhakar Raja Subramaniam et al.
PROGRESS IN NEUROBIOLOGY (2013)
Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease
Giuseppa Mudo et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2012)
Detecting differential usage of exons from RNA-seq data
Simon Anders et al.
GENOME RESEARCH (2012)
Sustained expression of PGC-1 in the rat nigrostriatal system selectively impairs dopaminergic function
C. Ciron et al.
HUMAN MOLECULAR GENETICS (2012)
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
Kelvin C. Luk et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
RNAscope A Novel in Situ RNA Analysis Platform for Formalin-Fixed, Paraffin-Embedded Tissues
Fay Wang et al.
JOURNAL OF MOLECULAR DIAGNOSTICS (2012)
Developmental Alterations in Motor Coordination and Medium Spiny Neuron Markers in Mice Lacking PGC-1α
Elizabeth K. Lucas et al.
PLOS ONE (2012)
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
Kelvin C. Luk et al.
SCIENCE (2012)
Mitochondrial Dysfunction in Neurodegenerative Diseases
Ashu Johri et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases
Yong Ren et al.
HUMAN MOLECULAR GENETICS (2011)
Estrogen related receptors (ERRs): A new dawn in transcriptional control of mitochondrial gene networks
Lillian J. Eichner et al.
MITOCHONDRION (2011)
Long-Range Neuronal Circuits Underlying the Interaction between Sensory and Motor Cortex
Tianyi Mao et al.
NEURON (2011)
Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
Laura A. Volpicelli-Daley et al.
NEURON (2011)
Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex
Srikripa Devarakonda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Clinical Progression in Parkinson Disease and the Neurobiology of Axons
Hsiao-Chun Cheng et al.
ANNALS OF NEUROLOGY (2010)
α-Synuclein impairs macroautophagy: implications for Parkinson's disease
Ashley R. Winslow et al.
JOURNAL OF CELL BIOLOGY (2010)
Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S
Xianting Li et al.
JOURNAL OF NEUROSCIENCE (2010)
PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson's Disease
Bin Zheng et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease
Hansruedi Bueeler
EXPERIMENTAL NEUROLOGY (2009)
Efficient Discovery of Selective Small Molecule Agonists of Estrogen-Related Receptor γ using Combinatorial Approach
Yongju Kim et al.
JOURNAL OF COMBINATORIAL CHEMISTRY (2009)
Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases
Brian Spencer et al.
JOURNAL OF NEUROSCIENCE (2009)
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
Xi Chen et al.
CELL (2008)
A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types
Myriam Heiman et al.
CELL (2008)
Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors
Vincent Giguere
ENDOCRINE REVIEWS (2008)
Phosphorylation-dependent sumoylation regulates estrogen-related receptor-α and -γ transcriptional activity through a synergy control motif
Annie M. Tremblay et al.
MOLECULAR ENDOCRINOLOGY (2008)
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
Tohru Kitada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
ERRγ directs and maintains the transition to oxidative metabolism in the postnatal heart
William A. Alaynick et al.
CELL METABOLISM (2007)
Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease
David Sulzer
TRENDS IN NEUROSCIENCES (2007)
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRα and γ
Catherine R. Dufour et al.
CELL METABOLISM (2007)
Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons
Mats I. Ekstrand et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
BioGRID: a general repository for interaction datasets
Chris Stark et al.
NUCLEIC ACIDS RESEARCH (2006)
Identification and structure -: Activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ
WJ Zuercher et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Clearance of α-synuclein oligomeric intermediates via the lysosomal degradation pathway
HJ Lee et al.
JOURNAL OF NEUROSCIENCE (2004)
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
MS Goldberg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
α-synuclein is degraded by both autophagy and the proteasome
JL Webb et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)