Hemodynamic effect of pimobendan following intramuscular and intravenous administration in healthy dogs: A pilot study

Article Veterinary Sciences

Cardiovascular effects of intravenous pimobendan in dogs with acute respiratory acidosis

Takaharu Itami et al.

Summary: The study aimed to evaluate the cardiovascular effects of pimobendan in dogs with induced respiratory acidosis, and found that pimobendan maintained positive inotropic effects in dogs with respiratory acidosis.

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE (2022)

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Article Veterinary Sciences

Changes in renin-angiotensin-aldosterone system during cardiac remodeling after mitral valvuloplasty in dogs

Chieh-Jen Cheng et al.

Summary: This study aimed to assess the longitudinal effects of mitral valvuloplasty (MVP) on circulating renin-angiotensin-aldosterone system (RAAS) activity. The results showed a significant decrease in RAAS activity after MVP, which correlated with the process of cardiac recovery.

JOURNAL OF VETERINARY INTERNAL MEDICINE (2022)

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Article Veterinary Sciences

Color M-Mode Echocardiography for Non-Invasive Assessment of the Intraventricular Pressure in Dogs Before and After Ductus Arteriosus Occlusion: A Retrospective Study

Miki Hirose et al.

Summary: This study evaluated the changes in IVPD and IVPG in dogs before and after surgical occlusion of PDA. The results showed a significant reduction in IVPD and IVPG after PDA closure, indicating a matched response to reduced preload. This study provides a preliminary exploration of the clinical application of CMME-derived IVPD and IVPG measurements in the evaluation of diastolic function in dogs with PDA.

FRONTIERS IN VETERINARY SCIENCE (2022)

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Article Veterinary Sciences

Hemodynamic Effects of Protamine Infusion in Dogs with Myxomatous Mitral Valve Disease Undergoing Mitral Valvuloplasty

Tomohiko Yoshida et al.

Summary: This study retrospectively described the hemodynamic effects of protamine administration in dogs undergoing cardiac surgery. Two dogs experienced severe hypotension, while others did not show significant hemodynamic changes. Epinephrine treatment and reboot of extracorporeal circulation were effective interventions for managing the catastrophic hypotension.

VETERINARY SCIENCES (2022)

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Article Veterinary Sciences

Effects of intravenous administration of pimobendan on hemodynamic indices and indices of left atrial longitudinal strain derived from speckle-tracking echocardiography in healthy dogs

Shingo Miki et al.

AMERICAN JOURNAL OF VETERINARY RESEARCH (2021)

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Article Agriculture, Dairy & Animal Science

The Utility of Intraventricular Pressure Gradient for Early Detection of Chemotherapy-Induced Subclinical Cardiac Dysfunction in Dogs

Katsuhiro Matsuura et al.

Summary: Early detection of doxorubicin-induced cardiomyopathy (DXR-ICM) is crucial to improve cancer patient outcomes and survival. IVPG indices are promising for the early diagnosis of cardiac dysfunction.

ANIMALS (2021)

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Article Agriculture, Dairy & Animal Science

Changes in the Pulmonary Artery Wave Reflection in Dogs with Experimentally-Induced Acute Pulmonary Embolism and the Effect of Vasodilator

Tomohiko Yoshida et al.

Summary: This study aimed to investigate the characteristics of PAWR in a dog model of APE and its response to vasodilator therapy. The results showed that PAWR is not only correlated with PVR but also with right ventricular function parameters, suggesting that PAWR may be a useful new evaluation method in PH.

ANIMALS (2021)

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Article Veterinary Sciences

Pharmacodynamics and Pharmacokinetics of Injectable Pimobendan and Its Metabolite, O-Desmethyl-Pimobendan, in Healthy Dogs

Poonavit Pichayapaiboon et al.

Summary: The study showed that intravenous pimobendan at the recommended dose for dogs can effectively increase cardiac contraction and output, accelerate cardiac relaxation, and decrease vascular resistance. These findings support the use of injectable pimobendan in the treatment of acute heart failure.

FRONTIERS IN VETERINARY SCIENCE (2021)

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Review Cardiac & Cardiovascular Systems