Impact of completion thyroidectomy on postoperative recovery in patients with differentiated thyroid cancer

While an increasing number of patients now undergo lobectomy for low-risk differentiated thyroid cancer, a subset of patients require completion thyroidectomy to facilitate radioactive iodine therapy. Completion thyroidectomy is generally as safe as the initial operation, but a previous study showed that a longer hospitalization is required for completion thyroidectomy. In this study, we reviewed 61 consecutive patients who had been treated with an initial lobectomy and subsequent completion thyroidectomy at our institution from 2012 to 2021. We detected a changepoint in 2016 for the proportion of patients who were treated with a thyroid lobectomy (Pettitt's test P = 0.049). The rate of completion thyroidectomy remained stable throughout the study period. There was no difference in operating time, intraoperative blood loss, perioperative drop in calcium levels, and postoperative hospital stay between surgeries. The patients reported higher pain scores on the day of operation (P = 0.007) and the postoperative day 1 (P = 0.022). Occult papillary microcarcinomas were identified in the contralateral thyroid lobe in 13 (21%) patients. Multifocality was the only predictor for residual malignancy in multivariate regression. In conclusion, patients with differentiated thyroid cancer experienced more pain in the immediate postoperative period following completion thyroidectomy. Hospital stays do not change with appropriate opioid-free pain control.

Automated summary

While an increasing number of patients undergo lobectomy for low-risk differentiated thyroid cancer, completion thyroidectomy may be needed for some patients to receive radioactive iodine therapy. This study found that completion thyroidectomy requires a longer hospital stay compared to the initial operation. However, there were no differences in operating time, intraoperative blood loss, perioperative drop in calcium levels, and postoperative hospital stay between surgeries. Patients reported higher pain scores on the day of operation and the first postoperative day. Occult papillary microcarcinomas were identified in the contralateral thyroid lobe in 21% of patients.