Freely Available, Fully Automated AI-Based Analysis of Primary Tumour and Metastases of Prostate Cancer in Whole-Body [18F]-PSMA-1007 PET-CT

Article Radiology, Nuclear Medicine & Medical Imaging

Analytical performance of aPROMISE: automated anatomic contextualization, detection, and quantification of [18F]DCFPyL (PSMA) imaging for standardized reporting

Kerstin Johnsson et al.

Summary: In this study, the deep learning algorithm demonstrated accurate segmentation, consistent quantitative assessment among multiple readers, and high sensitivity in detecting potential lesions in PSMA PET/CT scans.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Assessment of malignancy and PSMA expression of uncertain bone foci in [18F]PSMA-1007 PET/CT for prostate cancer-a single-centre experience of PET-guided biopsies

Bernd Vollnberg et al.

Summary: This study examined the issue of uncertain focal bone uptake and intensive radiopharmaceutical avidity in patients with prostate cancer undergoing [F-18]PSMA-1007 PET/CT. The results of PET-guided biopsies revealed a small number of true metastases and benign bone tissue without PSMA expression, suggesting an unclear non-PSMA mediated cause for the radiopharmaceutical uptake.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Freely available artificial intelligence for pelvic lymph node metastases in PSMA PET-CT that performs on par with nuclear medicine physicians

Elin Tragardh et al.

Summary: The study developed and validated an artificial intelligence-based method using convolutional neural networks for the detection of pelvic lymph node metastases in patients with high-risk prostate cancer. The AI method showed comparable sensitivity with human readers and emphasized the importance of automated methods in clinical diagnosis.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Measuring response in metastatic castration-resistant prostate cancer using PSMA PET/CT: comparison of RECIST 1.1, aPCWG3, aPERCIST, PPP, and RECIP 1.0 criteria

Andrei Gafita et al.

Summary: The purpose of this study is to compare the differences and reliabilities among different criteria for response evaluation using PSMA-PET/CT in men with mCRPC treated with Lu-177-PSMA. The results showed that PSMA-PET-specific criteria achieved better performance in predicting the risk of death and identifying PD vs no-PD.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Review Urology & Nephrology

Radiomics in prostate cancer: an up-to-date review

Matteo Ferro et al.

Summary: This article provides an overview of the application of radiomics in prostate cancer patients, emphasizing its potential for personalized treatment and future applications.

THERAPEUTIC ADVANCES IN UROLOGY (2022)

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Article Physiology

Artificial intelligence-based detection of lymph node metastases by PET/CT predicts prostate cancer-specific survival

Pablo Borrelli et al.

Summary: Utilizing an AI-based tool for automated and objective interpretation of PET/CT images can provide lymph node lesion assessments comparable to experienced readers, and is significantly associated with PCa-specific survival.

CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Quantification of Metastatic Prostate Cancer Whole-Body Tumor Burden with 18F-FDG PET Parameters and Associations with Overall Survival After First-Line Abiraterone or Enzalutamide: A Single-Center Retrospective Cohort Study

Andreas G. Wibmer et al.

Summary: The study evaluated the prognostic value of F-18-FDG PET whole-body tumor burden parameters in patients with metastatic prostate cancer receiving different treatments. The results showed a significant correlation between whole-body tumor burden parameters and overall survival in patients with metastatic castration-resistant prostate cancer, while no significant association was observed in patients with metastatic castration-sensitive prostate cancer.

JOURNAL OF NUCLEAR MEDICINE (2021)

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Review Medicine, General & Internal

Nuclear Imaging for Bone Metastases in Prostate Cancer: The Emergence of Modern Techniques Using Novel Radiotracers

Wietske I. Luining et al.

Summary: Accurate staging and treatment strategy are crucial for prognosis in prostate cancer. Traditional imaging techniques like CT and bone scintigraphy have limitations in sensitivity and specificity compared to modern nuclear imaging methods using novel radiotracers with PET/CT technology, which outperform conventional imaging in detecting PCa.

DIAGNOSTICS (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

E-PSMA: the EANM standardized reporting guidelines v1.0 for PSMA-PET

Francesco Ceci et al.

Summary: The development of consensus guidelines for interpretation of PSMA-PET aims to provide consistent clinical reports, increase data reproducibility in clinical trials, and assist clinicians in making treatment decisions. An expert panel actively participated in a modified Delphi consensus process to implement structured reporting for PSMA-PET. The E-PSMA standardized reporting guidelines supported by the European Association of Nuclear Medicine offer consensus statements among experts in PSMA-PET imaging to harmonize diagnostic interpretation criteria.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Can PSMA-based tumor burden predict response to docetaxel treatment in metastatic castration-resistant prostate cancer?

Duygu Has Simsek et al.

Summary: The study found that mCRPC patients with high TV-PSMA and TL-PSMA, high LDH, among other factors, had a poorer PSA response to DTX treatment and significantly shorter survival time.

ANNALS OF NUCLEAR MEDICINE (2021)

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Review Medicine, General & Internal

Diagnostic Role of 18F-PSMA-1007 PET/CT in Prostate Cancer Staging: A Systematic Review

Salam Awenat et al.

Summary: F-18-PSMA-1007 PET/CT demonstrates good diagnostic accuracy for PCa staging, showing similar results compared to other PSMA-targeted radiopharmaceuticals. This method has the potential to replace traditional imaging techniques for PCa staging. Prospective multicentric studies are needed to confirm these findings.

DIAGNOSTICS (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Focal unspecific bone uptake on [18F]-PSMA-1007 PET: a multicenter retrospective evaluation of the distribution, frequency, and quantitative parameters of a potential pitfall in prostate cancer imaging

Hannes Gruenig et al.

Summary: Improved logistics and availability have led to a rapid increase in the use of [F-18]-PSMA-1007 for prostate cancer PET imaging. Initial data suggest increased uptake in benign lesions compared to [(68)Ga]-PSMA-11, and clinical observations found increased unspecific bone uptake (UBU). UBUs occur in two-thirds of patients imaged with [F-18]-PSMA-1007 PET/CT and are significantly more frequent on digital PET scanners than analog scanners, highlighting the need for careful interpretation to avoid over-staging.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Review Biochemistry & Molecular Biology

Prostate Cancer Radiogenomics-From Imaging to Molecular Characterization

Matteo Ferro et al.

Summary: Radiomics and genomics play crucial roles in prostate cancer research, enhancing clinical value through mathematical analysis and machine learning. Validation of recent findings in large, randomized cohorts can establish the role of radiogenomics in the future.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Urology & Nephrology