Journal
DIAGNOSTICS
Volume 12, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/diagnostics12082025
Keywords
previable PPROM; preterm rupture of membranes; PTB; preterm delivery; antibiotics
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This study reviews the challenges and treatment options for preterm premature rupture of the membranes at the limit of viability, and proposes possible directions for future development.
Preterm premature rupture of the membranes (PPROM) at the limit of viability is associated with low neonatal survival rates and a high rate of neonatal complications in survivors. It carries a major risk of maternal morbidity and mortality. The limit of viability can be defined as the earliest stage of fetal maturity when a fetus has a reasonable chance, although not a high likelihood, for extra-uterine survival. The study reviews available data on preventing preterm delivery caused by the previable PPROM, pregnancy latency, therapeutic options including the use of antibiotics and steroids, neonatal outcomes, and future directions and opportunities.
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