Journal
ACS OMEGA
Volume 7, Issue 39, Pages 35077-35082Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.2c03963
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Funding
- Universidad Nacional Autonoma de Mexico [PAPIIT IG200821]
- Consejo Nacional de Ciencia y Tecnologia (CONACYT Grant) [651375]
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A new natural compound, 25,26,27-trisnor-3P-hydroxy-euphan-24-al (1), was isolated from the leaves of Euphorbia tanquahuete for the first time. In addition, several known compounds and derivatives were also identified. Biological assays showed that compound 1 and semisynthetic compound 8 exhibited the most activity against leukemia cell line (K562).
The natural compound 25,26,27-trisnor-3P-hydroxy-euphan-24-al (1) was isolated for the first time from the bioactive extract of the leaves of Euphorbia tanquahuete, together with the known compounds euphol, eupha-8,23-dien-3P,25-diol, lupeol, cycloeucalenol, P-sitosterol, squalene, and 1-octacosanol. The structure of the new compound was elucidated based on extensive analysis of spectroscopic data and by semisynthesis from euphol. The chemical modification of the alcohol at C3 and the side chain of euphol afforded seven derivatives (6-12). The cytotoxic activity of the natural and semisynthetic compounds evaluated against a panel of human cancer cell lines showed selectivity for certain cell lines and indicated that natural compound 1 and semisynthetic 8 were the most active against leukemia (K562) cell line.
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