Journal
ACS OMEGA
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.2c05350
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Funding
- Education Department, Government of Gujarat [201901420008, 201901420005, 201901420003]
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Here, a synthetic protocol for the synthesis of carbamates using zinc chloride as a catalyst is reported. The protocol has been successfully applied to the gram-scale synthesis of FDA-approved drugs and their derivatives, with yields ranging from 49-87%. The utility of zinc chloride is demonstrated over other catalysts such as zinc dust and zinc acetate.
Herein, we report a synthetic protocol for the synthesis of carbamates by employing zinc chloride as a catalyst from carbamoyl chlorides and aromatic/aliphatic alcohols. The developed protocol successfully utilizes the gram-scale synthesis of the FDA-approved rivastigmine drug and its derivative. The utility of zinc chloride over other catalysts such as zinc dust and zinc acetate exhibits a 49-87% yield of carbamates.
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