Journal
PLANTS-BASEL
Volume 11, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/plants11212951
Keywords
Malvaviscus arboreus; kaempferol-3-O-sambubioside and kaempferol-3-O-sophoroside; cytokines; histologic analysis; catalase
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Funding
- CONACyT [626088, IMSS 99186778]
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A mixture of Kaempferol-O-sambubioside and Kaempferol-O-sophoroside (MaSS) isolated from Malvaviscus arboreus flowers can prevent ethanol-induced gastric lesions and possess anti-inflammatory and antioxidant activities.
Malvaviscus arboreus is used in traditional Mexican medicine to treat gastrointestinal diseases. Therefore, a mixture of Kaempferol-O-sambubioside and Kaempferol-O-sophoroside (MaSS) isolated from flowers of this species was tested as a preventive treatment on gastric lesions induced with ethanol in rats. MaSS was obtained by chromatographic methods and administered by oral pathway to male Sprague Dawley rats with ethanol-induced gastric lesions. Pretreatment with MaSS at doses of 30, 90, 120, and 180 mg/kg significantly prevents gastric lesions, inhibits the increment in relative stomach weight (%) in gastric IL-6, and also provokes an increment of IL-10 concentration and catalase activity. Finally, MaSS prevented edema in the mucosa and submucosa and diminished microscopic gastric lesions provoked by ethanol.
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