Journal
PLANTS-BASEL
Volume 11, Issue 20, Pages -Publisher
MDPI
DOI: 10.3390/plants11202750
Keywords
broccoli sprouts; thyroid; cancer; hypothyroidism; rats
Categories
Funding
- Polish Ministry of Education and Science [N42/DBS/000167, N42/DBS/000283]
- qLIFE Priority Research Area under the program Excellence Initiative-Research University at Jagiellonian University [06/IDUB/2019/94]
Ask authors/readers for more resources
This study aimed to evaluate the effects of broccoli sprouts on thyroid cells and rats. The results showed that broccoli sprouts can decrease the viability of thyroid cancer cells and prevent inflammation. The study also confirmed the safety of broccoli sprouts, but further research is needed.
Broccoli sprouts are a super vegetable; however, they have possible negative effects on thyroid function, which is especially important for patients with hypothyroidism. As the data on this issue are scarce, this study aimed to determine the safety and possible beneficial effect of broccoli sprouts both in vitro and in vivo. The in vitro model comprised the evaluation of the impact of broccoli sprouts on normal and neoplastic thyroid cells and the determination of their anti-inflammatory and antioxidant (IL-6, TNF-alpha, NO, and SOD) potential in macrophages. The in vivo model concerned the histopathological analysis of thyroid glands in healthy rats and rats with hypothyroidism (induced by iodine deficiency or sulfadimethoxine ingestion) fed with broccoli sprouts. The results of our study indicated that broccoli sprouts decreased the viability of thyroid cancer cells and prevented inflammation. The results also confirmed the satisfactory safety profile of the sprouts, both in vitro and in vivo; however, a further in-depth evaluation of this problem is still needed. Information on the influence of brassica vegetables on thyroid function is of great importance in terms of public health, particularly when taking into account that the risk of iodine deficiency, hypothyroidism, and thyroid cancer in the global population is still increasing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available