Temporal Stability of Dynamic Default Mode Network Connectivity Negatively Correlates with Suicidality in Major Depressive Disorder

Previous studies have demonstrated that the suicidality in patients with major depressive disorder (MDD) is related to abnormal brain functional connectivity (FC) patterns. However, little is known about its relationship with dynamic functional connectivity (dFC) based on the assumption that brain FCs fluctuate over time. Temporal stabilities of dFCs within the whole brain and nine key networks were compared between 52 MDD patients and 21 age, sex-matched healthy controls (HCs) using resting-state functional magnetic resonance imaging and temporal correlation coefficients. The alterations in MDD were further correlated with the scores of suicidality item in the Hamilton Rating Scale for Depression (HAMD). Compared with HCs, the MDD patients showed a decreased temporal stability of dFC as indicated by a significantly decreased temporal correlation coefficient at the global level, as well as within the default mode network (DMN) and subcortical network. In addition, temporal correlation coefficients of the DMN were found to be significantly negatively correlated with the HAMD suicidality item scores in MDD patients. These results suggest that MDD may be characterized by excessive temporal fluctuations of dFCs within the DMN and subcortical network, and that decreased stability of DMN connectivity may be particularly associated with the suicidality in MDD.

Automated summary

Previous studies have shown that suicidality in patients with major depressive disorder (MDD) is related to abnormal brain functional connectivity (FC) patterns. This study investigated the relationship between suicidality and dynamic functional connectivity (dFC) in MDD patients and found that MDD patients had decreased temporal stability of dFC in the whole brain, as well as within the default mode network (DMN) and subcortical network. Additionally, the temporal correlation coefficients of the DMN were negatively correlated with the scores of suicidality item in the Hamilton Rating Scale for Depression (HAMD) in MDD patients.