☆ 4.6 Article

Azole-Based Compounds That Are Active against Candida Biofilm: In Vitro, In Vivo and In Silico Studies

ANTIBIOTICS-BASEL (2022)

Related references

Note: Only part of the references are listed.

Article Biochemistry & Molecular Biology

Antifungal and Anti-Virulent Activity of Origanum majorana L. Essential Oil on Candida albicans and In Vivo Toxicity in the Galleria mellonella Larval Model

Banu Kaskatepe et al.

Summary: This study investigated and compared the antifungal activity and essential oil composition of naturally growing and cultivated samples of marjoram. The results showed that both samples of marjoram essential oil exhibited strong antifungal activity against Candida spp. Additionally, the essential oils showed inhibition of biofilm formation and germ-tube formation, which are virulence factors of Candida albicans.

MOLECULES (2022)

Add to Collection

Review Pharmacology & Pharmacy

Drug design strategies for the treatment azole-resistant candidiasis

Setareh Moghimi et al.

Summary: Despite the availability of new antifungal drugs, the mortality rate of invasive fungal diseases caused by fungal infection remains high. This review article focuses on the efforts to find effective drugs against azole-resistant candidiasis, covering azole-based compounds, dual target drugs, and new scaffolds. The mechanism of action and SAR studies are also discussed. Experts believe that novel scaffolds/compounds can be found using methods like virtual screening and fragment-based drug discovery.

EXPERT OPINION ON DRUG DISCOVERY (2022)

Add to Collection

Article Chemistry, Medicinal

Design, synthesis and biological evaluation of imidazole and triazole-based carbamates as novel aromatase inhibitors

Alessandra Ammazzalorso et al.

Summary: Novel aromatase inhibitors based on triazole and imidazole-based carbamate derivatives were designed and synthesized, with compounds 13a and 15c showing dose-dependent inhibition of cell viability on the human breast cancer cell line MCF7. Docking simulations were also carried out to elucidate the binding modes of these active compounds to target human aromatase at a molecular level.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Add to Collection

Article Infectious Diseases

Inhibitory effect of polyunsaturated fatty acids alone or in combination with fluconazole on Candida krusei biofilms in vitro and in Caenorhabditis elegans

Abdullahi Temitope Jamiu et al.

Summary: The incidence of infections caused by non-albicans Candida species, including Candida krusei, is increasing, and these infections show resistance to fluconazole and can form biofilms. This study found that linoleic acid (LA) and gamma-linolenic acid (GLA) can inhibit C. krusei biofilms and increase their susceptibility to fluconazole by inducing oxidative stress, cell membrane damage, and disrupting efflux pump activity. These PUFAs also prolonged the lifespan of infected nematodes and showed a synergistic effect with fluconazole, suggesting a potential new treatment strategy for combating infections caused by C. krusei.

MEDICAL MYCOLOGY (2021)

Add to Collection

Review Immunology

Fungal immunity and pathogenesis in mammals versus the invertebrate model organism Galleria mellonella

Daniel F. Q. Smith et al.

Summary: Galleria mellonella has emerged as a model system for studying fungal pathogenesis due to its advantages of speed, low cost, high throughput, and minimal ethical and regulatory concerns compared to vertebrate models. Research suggests that the immune systems of G. mellonella and mammals share similarities, and fungal virulence factors function similarly in both hosts. However, there are gaps in knowledge concerning specific mechanisms underlying G. mellonella-fungal interactions that need to be addressed in order to strengthen the model's viability for studying fungal virulence in the future.

PATHOGENS AND DISEASE (2021)

Add to Collection

Review Biochemistry & Molecular Biology

A Highlight on the Inhibition of Fungal Carbonic Anhydrases as Drug Targets for the Antifungal Armamentarium

Claudiu T. Supuran et al.

Summary: Carbon dioxide plays a crucial role in biological metabolism and is regulated by a superfamily of enzymes called carbonic anhydrases (CAs). Fungi can sense environmental CO2 levels and their virulence or survival traits are influenced by this sensing mechanism. Inhibiting CAs can impair fungal growth and virulence, making them a potential target for novel antifungal drugs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Infectious Diseases

Galleria mellonella: The Versatile Host for Drug Discovery, In Vivo Toxicity Testing and Characterising Host-Pathogen Interactions

Magdalena Piatek et al.

Summary: The larvae of the greater wax moth, Galleria mellonella, serve as a convenient and cost-effective in vivo model for evaluating the activity and toxicity of antimicrobial agents, studying immune responses, and characterizing disease progression. Their use can accelerate the development of novel antimicrobials and may be a prerequisite to mammalian testing.

ANTIBIOTICS-BASEL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Health Potential of Clery Strawberries: Enzymatic Inhibition and Anti-Candida Activity Evaluation

Francesco Cairone et al.

Summary: The study focused on strawberries of cultivar Clery, evaluating their inhibitory effects on various enzymes. The results demonstrate the potential medicinal benefits of strawberries when processed correctly.

MOLECULES (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Geraniol eradicates Candida glabrata biofilm by targeting multiple cellular pathways

Payal Gupta et al.

Summary: The research evaluated the antifungal activity of geraniol against Candida glabrata biofilm, discovering multiple mechanisms including biofilm eradication, cellular pathway interference, and induction of apoptosis. These findings strengthen the candidacy of geraniol as a novel antifungal therapeutic.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking study

Cristina Maccallini et al.

Summary: New indazole and triazole derivatives were synthesized and evaluated for their potential dual activities as agents targeting both aromatase and inducible nitric oxide synthase. Some compounds showed promising effects in treating breast cancer and also exhibited antifungal properties against Candida strains.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Fungal Lanosterol 14α-demethylase: A target for next-generation antifungal design

Brian C. Monk et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2020)

Add to Collection

Article Chemistry, Medicinal

Synthesis and biological evaluation of Vinpocetine derivatives

Bo-Wen Pan et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2020)

Add to Collection

Review Infectious Diseases

Molecular and genetic basis of azole antifungal resistance in the opportunistic pathogenic fungus Candida albicans

Andrew T. Nishimoto et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

Add to Collection

Article Integrative & Complementary Medicine

Anti-Candida albicans biofilm activity of extracts from two selected indigenous Algerian plants: Clematis flammula and Fraxinus angustifolia

Asma Ourabah et al.

JOURNAL OF HERBAL MEDICINE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors

OEzlen Guezel-Akdemir et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Review Microbiology

The Still Underestimated Problem of Fungal Diseases Worldwide

Fausto Almeida et al.

FRONTIERS IN MICROBIOLOGY (2019)

Add to Collection

Review Infectious Diseases

Resistance of Candida to azoles and echinocandins worldwide

K. E. Pristov et al.

CLINICAL MICROBIOLOGY AND INFECTION (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Anti-Candida Biofilm Activity of Pterostilbene or Crude Extract from Non-Fermented Grape Pomace Entrapped in Biopolymeric Nanoparticles

Giovanna Simonetti et al.

MOLECULES (2019)

Add to Collection

Review Microbiology

Candida albicans biofilm growth and dispersal: contributions to pathogenesis

Gina Wall et al.

CURRENT OPINION IN MICROBIOLOGY (2019)

Add to Collection

Review Chemistry, Medicinal

New and Promising Chemotherapeutics for Emerging Infections Involving Drug-resistant Non-albicans Candida Species

Laura Nunes Silva et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2019)

Add to Collection

Review Microbiology

Antifungal drug resistance: evolution, mechanisms and impact

Nicole M. Revie et al.

CURRENT OPINION IN MICROBIOLOGY (2018)

Add to Collection

Review Microbiology

A Proposal of Remedies for Oral Diseases Caused by Candida: A Mini Review

Tomoko Ohshima et al.

FRONTIERS IN MICROBIOLOGY (2018)

Add to Collection

Review Microbiology

Therapy of Skin, Hair and Nail Fungal Infections

Roderick Hay

JOURNAL OF FUNGI (2018)

Add to Collection

Article Infectious Diseases

The global problem of antifungal resistance: prevalence, mechanisms, and management

David S. Perlin et al.

LANCET INFECTIOUS DISEASES (2017)

Add to Collection

Review Microbiology

Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species

Sarah G. Whaley et al.

FRONTIERS IN MICROBIOLOGY (2017)

Add to Collection

Review Microbiology

Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision

Felix Bongomin et al.

JOURNAL OF FUNGI (2017)

Add to Collection

Article Immunology

The Global Burden of Fungal Diseases

Snigdha Vallabhaneni et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2016)

Add to Collection

Review Immunology

Candida albicans biofilms: development, regulation, and molecular mechanisms

Megha Gulati et al.

MICROBES AND INFECTION (2016)

Add to Collection

Review Infectious Diseases

Azole antifungals: 35 years of invasive fungal infection management

David Allen et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2015)

Add to Collection

Review Pharmacology & Pharmacy

TRIAZOLE ANTIFUNGALS: A REVIEW

L. R. Peyton et al.

DRUGS OF TODAY (2015)

Add to Collection

Article Chemistry, Medicinal

Activity of caffeic acid derivatives against Candida albicans biofilm

Daniela De Vita et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Add to Collection

Editorial Material Immunology

Galleria mellonella as a model host to study virulence of Candida

Ilse D. Jacobsen

VIRULENCE (2014)

Add to Collection

© Peeref 2019-2024. All rights reserved.