4.7 Article

A Sulfated Polysaccharide from Red Algae (Gelidium crinale) to Suppress Cells Metastasis and MMP-9 Expression of HT1080 Cells

Journal

FOODS
Volume 11, Issue 15, Pages -

Publisher

MDPI
DOI: 10.3390/foods11152360

Keywords

sulfated polysaccharides; Gelidium crinale; MMP-9; migration; invasion

Funding

  1. Development Project about Marine Economy Demonstration of Zhanjiang City [XM-202008-01B1]
  2. 2020 Shenzhen International Scientific and Technological Cooperation RD Project [GJHZ20190823111601682]
  3. Natural Science Foundation of Guangdong Province [2020A1515011075]
  4. Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang) [ZJW-2019-07]

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Sulfated polysaccharides from red algae have antitumor activities. In this study, it was found that the sulfated polysaccharide from Gelidium crinale can inhibit the migration and invasion of human fibrosarcoma cells and suppress the expression and activity of MMP-9 by regulating NF-kappa B, MAPK, and mTOR/PI3K/Akt signaling pathways. This suggests that GNP may serve as an MMP-9 inhibitor for preventing tumor metastasis.
Sulfated polysaccharides from red algae have a variety of biological activities, especially antitumor activities. Matrix metalloproteinase-9 (MMP-9) is a proteolytic metalloenzyme that degrades the central part of the extracellular matrix (ECM) and promotes tumor metastasis. In this research, we have investigated the influence and mechanism of GNP (sulfated polysaccharide from Gelidium crinale) on tumor metastasis and MMP-9 expression of human fibrosarcoma (HT1080) cells. The results inflected that the concentration of GNP below 100 mu g/mL has no toxicity to HT1080 cells, but showed excellent activity in inhibiting cells migration and invasion. In addition, GNP effectively inhibits the mRNA of MMP-9 and reduces its expression and activity by regulating nuclear factor-kappa B (NF-kappa B), mitogen-activated protein kinases (MAPK) and mTOR/PI3K/Akt signaling pathways. GNP has great potential as MMP-9 inhibitor and could be developed as a functional food or drug to prevent tumor metastasis.

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