Journal
FOODS
Volume 11, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/foods11162533
Keywords
controlled delivery; ethyl cellulose; polyethylene glycol; release models; retinoic acid; spray-drying
Categories
Funding
- FCT/MCTES (PIDDAC) [LA/P/0045/2020, UIDB/00511/2020, UIDP/00511/2020]
- FEDER funds through COMPETE2020-Programa Operacional Competitividade e Internacionalizacao (POCI) [POCI-01-0145-FEDER-028715]
- FCT/MCTES
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Microparticles based on ethyl cellulose were prepared using the spray-drying process for the encapsulation of retinoic acid. The results showed that these microparticles had a suitable controlled delivery system and exhibited good encapsulation efficiency and release rate.
Ethyl cellulose (EC)-based microparticles, with and without the incorporation of polyethylene glycol (PEG) as a second encapsulating agent, were prepared using the spray-drying process for the encapsulation of retinoic acid (RA). The production of a suitable controlled delivery system for this retinoid will promote its antitumor efficiency against acute promyelocytic leukemia (APL) due to the possibility of increasing the bioavailability of RA. Product yield ranged from 12 to 28% in all the microparticle formulations, including unloaded microparticles and RA-loaded microparticles. Microparticles with a mean diameter between 0.090 +/- 0.002 and 0.54 +/- 0.02 mu m (number size distribution) and with an irregular form and rough surface were obtained. Furthermore, regarding RA-loaded microparticles, both polymer-based formulations exhibited an encapsulation efficiency of around 100%. A rapid and complete RA release was reached in 40 min from EC- and EC + PEG-based microparticles.
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