Journal
JOURNAL OF MEDICINAL FOOD
Volume 19, Issue 5, Pages 481-485Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2016.0005
Keywords
glucose; insulin; prediabetes; Russian tarragon
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To evaluate the effect of Artemisia dracunculus on glycemic control, insulin sensitivity, and insulin secretion in patients with impaired glucose tolerance (IGT). A randomized, double blind, placebo-controlled clinical trial was performed in 24 patients with diagnosis of IGT. Before and after the intervention, glucose and insulin levels were measured every 30min for 2h after a 75-g dextrose load, along with glycated hemoglobin A1c (A1C) and lipid profile. Twelve patients received A. dracunculus (1000mg) before breakfast and dinner for 90 days; the remaining 12 patients received placebo. Area under the curve (AUC) of glucose and insulin, total insulin secretion, first phase of insulin secretion, and insulin sensitivity were calculated. Wilcoxon signed-rank, Mann-Whitney U, and chi-square tests were used for statistical analyses. The institutional ethics committee approved the protocol. After A. dracunculus administration, there were significant decreases in systolic blood pressure (SBP; 120.0 +/- 11.3 vs. 113.0 +/- 11.2mmHg, P<.05), A1C (5.8 +/- 0.3 vs. 5.6%+/- 0.4%, P<.05), AUC of insulin (56,136.0 +/- 27,426.0 vs. 44,472.0 +/- 23,370.0 pmol/L, P<.05), and total insulin secretion (0.45 +/- 0.23 vs. 0.35 +/- 0.18, P<.05), with a significant increase in high-density lipoprotein cholesterol (HDL-C) (1.3 +/- 0.3 vs. 1.4 +/- 0.3 mmol/L, P<.05). There were no significant differences after placebo administration. A. dracunculus administration for 90 days in patients with IGT significantly decreased SBP, A1C, AUC of insulin, and total insulin secretion with a significant increase in HDL-C levels.
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